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    Gemin6 gem (nuclear organelle) associated protein 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362688, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gemin6provided by RGD
    Official Full Name
    gem (nuclear organelle) associated protein 6provided by RGD
    Primary source
    RGD:1311168
    See related
    EnsemblRapid:ENSRNOG00000027332 AllianceGenome:RGD:1311168
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in spliceosomal snRNP assembly. Predicted to be located in Gemini of coiled bodies and cytosol. Predicted to be part of SMN complex. Orthologous to human GEMIN6 (gem nuclear organelle associated protein 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 132.9), Liver (RPKM 131.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gemin6 in Genome Data Viewer
    Location:
    6q12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (20538325..20542867, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (14786090..14790617, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (2907040..2911577)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 33 Neighboring gene eukaryotic translation initiation factor 4A2, pseudogene 2 Neighboring gene MORN repeat containing 2 Neighboring gene DExH-box helicase 57 Neighboring gene tetratricopeptide repeat domain 39D Neighboring gene serine and arginine rich splicing factor 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis. Yong J, et al. Mol Cell, 2010 May 28. PMID 20513430, Free PMC Article
    2. Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component. Pellizzoni L, et al. J Biol Chem, 2002 Mar 1. PMID 11748230
    3. An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. Chari A, et al. Cell, 2008 Oct 31. PMID 18984161
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in spliceosomal complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal snRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal snRNP assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Gemini of coiled bodies ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SMN complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SMN complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SMN-Sm protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    gem-associated protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009466.3 → NP_001009466.2  gem-associated protein 6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6H9R3, G3V972, Q5JCM4
      Related
      ENSRNOP00000037414.2, ENSRNOT00000037739.4
      Conserved Domains (1) summary
      pfam06372
      Location:1 → 166
      Gemin6; Gemin6 protein

    2. NM_001395136.1 → NP_001382065.1  gem-associated protein 6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6H9R3, G3V972, Q5JCM4
      Conserved Domains (1) summary
      pfam06372
      Location:1 → 166
      Gemin6; Gemin6 protein

    3. NM_001395137.1 → NP_001382066.1  gem-associated protein 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      Related
      ENSRNOP00000111913.1, ENSRNOT00000159966.1
      Conserved Domains (1) summary
      cl00259
      Location:1 → 107
      Sm_like; Sm and related proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      20538325..20542867 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262048.1 → XP_063118118.1  gem-associated protein 6 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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