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    Ndufs5 NADH:ubiquinone oxidoreductase subunit S5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362588, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ndufs5provided by RGD
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit S5provided by RGD
    Primary source
    RGD:1311081
    See related
    EnsemblRapid:ENSRNOG00000026646 AllianceGenome:RGD:1311081
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ndufs5b
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Orthologous to human NDUFS5 (NADH:ubiquinone oxidoreductase subunit S5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 2134.6), Muscle (RPKM 1143.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ndufs5 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (141258828..141264552, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (135974029..135979705, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (141390577..141405507, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene microtubule-actin crosslinking factor 1 Neighboring gene U6 spliceosomal RNA Neighboring gene 40S ribosomal protein S15a pseudogene Neighboring gene uncharacterized LOC120103124 Neighboring gene akirin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Coupling mitochondrial respiratory chain to cell death: an essential role of mitochondrial complex I in the interferon-beta and retinoic acid-induced cancer cell death. Huang G, et al. Cell Death Differ, 2007 Feb. PMID 16826196
    2. Human complex I defects can be resolved by monoclonal antibody analysis into distinct subunit assembly patterns. Triepels RH, et al. J Biol Chem, 2001 Mar 23. PMID 11112787
    3. Accessory subunits are integral for assembly and function of human mitochondrial complex I. Stroud DA, et al. Nature, 2016 Oct 6. PMID 27626371
    4. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. Murray J, et al. J Biol Chem, 2003 Apr 18. PMID 12611891
    5. Architecture of Human Mitochondrial Respiratory Megacomplex I(2)III(2)IV(2). Guo R, et al. Cell, 2017 Sep 7. PMID 28844695

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
    Names
    NADH dehydrogenase (ubiquinone) Fe-S protein 5
    NADH dehydrogenase (ubiquinone) Fe-S protein 5b, 15kDa (NADH-coenzyme Q reductase)
    NP_001025223.1
    XP_006238889.1
    XP_006238890.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030052.1 → NP_001025223.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

      See identical proteins and their annotated locations for NP_001025223.1

      Status: PROVISIONAL

      Source sequence(s)
      AW525881, CB716681
      UniProtKB/TrEMBL
      A0A0G2JZJ9, A0A9K3Y8A9, B5DEL8
      Related
      ENSRNOP00000037699.4, ENSRNOT00000036389.7
      Conserved Domains (1) summary
      pfam10200
      Location:2 → 96
      Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      141258828..141264552 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238827.5 → XP_006238889.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006238889.1

      UniProtKB/TrEMBL
      A0A0G2JZJ9, A0A9K3Y8A9, B5DEL8
      Conserved Domains (1) summary
      pfam10200
      Location:2 → 96
      Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

    2. XM_006238828.5 → XP_006238890.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006238890.1

      UniProtKB/TrEMBL
      A0A0G2JZJ9, A0A9K3Y8A9, B5DEL8
      Conserved Domains (1) summary
      pfam10200
      Location:2 → 96
      Ndufs5; NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
    Nucleotide Protein Strain
    Heading Accession and Version

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