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    Tuft1 tuftelin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365864, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Tuft1provided by RGD
    Official Full Name
    tuftelin 1provided by RGD
    Primary source
    RGD:1310373
    See related
    EnsemblRapid:ENSRNOG00000020923 AllianceGenome:RGD:1310373
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be a structural constituent of skin epidermis. Predicted to be located in cytoplasm. Predicted to be part of RNA polymerase II, core complex. Predicted to be active in I band. Orthologous to human TUFT1 (tuftelin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 99.9), Lung (RPKM 88.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tuft1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (184949437..184995321, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (182259457..182306296, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (195861772..195907471, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene sorting nexin 27 Neighboring gene uncharacterized LOC134485647 Neighboring gene nuclear receptor binding factor 2 like 1 Neighboring gene uncharacterized LOC120100872 Neighboring gene uncharacterized LOC134485648 Neighboring gene cingulin Neighboring gene NADH:ubiquinone oxidoreductase subunit S5, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Spontaneous nonsense mutation in the tuftelin 1 gene is associated with abnormal hair appearance and amelioration of glucose and lipid metabolism in the rat. Šilhavý J, et al. Physiol Genomics, 2024 Jan 1. PMID 37955133
    2. The expression of tuftelin 1 as a new theranostic marker in early diagnosis and as a therapeutic target in hepatocellular carcinoma. Abdel-Hamid NM, et al. Cell Biochem Funct, 2023 Oct. PMID 37470499
    3. Tuftelin Is Required for NGF-Induced Differentiation of PC12 Cells. Shilo D, et al. J Mol Neurosci, 2019 May. PMID 30903486
    4. Long Non-coding RNA BC168687 is Involved in TRPV1-mediated Diabetic Neuropathic Pain in Rats. Liu C, et al. Neuroscience, 2018 Mar 15. PMID 29421435
    5. The induction of tuftelin expression in PC12 cell line during hypoxia and NGF-induced differentiation. Leiser Y, et al. J Cell Physiol, 2011 Jan. PMID 20658530

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spontaneous nonsense mutation in the tuftelin 1 gene is associated with abnormal hair appearance and amelioration of glucose and lipid metabolism in the rat.
      Title: Spontaneous nonsense mutation in the tuftelin 1 gene is associated with abnormal hair appearance and amelioration of glucose and lipid metabolism in the rat.
    2. The expression of tuftelin 1 as a new theranostic marker in early diagnosis and as a therapeutic target in hepatocellular carcinoma.
      Title: The expression of tuftelin 1 as a new theranostic marker in early diagnosis and as a therapeutic target in hepatocellular carcinoma.
    3. Tuftelin is essential for NGF-induced differentiation of PC12 cells.
      Title: Tuftelin Is Required for NGF-Induced Differentiation of PC12 Cells.
    4. The pathways affecting the expression of tuftelin in PC12 cells and mice are described.
      Title: The induction of tuftelin expression in PC12 cell line during hypoxia and NGF-induced differentiation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188530

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of skin epidermis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in I band IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tuftelin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360750.1 → NP_001347679.1  tuftelin

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A0G2JZ65, B5DEI8, D3ZKZ5
      Related
      ENSRNOP00000070926.2, ENSRNOT00000079776.3
      Conserved Domains (1) summary
      cl25732
      Location:66 → 314
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      184949437..184995321 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232890.5 → XP_006232952.1  tuftelin isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZX33
      Related
      ENSRNOP00000074336.3, ENSRNOT00000089402.3
      Conserved Domains (3) summary
      pfam06364
      Location:150 → 231
      DUF1068; Protein of unknown function (DUF1068)
      cd16269
      Location:322 → 332
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:217 → 349
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. XM_063282271.1 → XP_063138341.1  tuftelin isoform X2

      UniProtKB/TrEMBL
      D3ZKZ5

    3. XM_063282272.1 → XP_063138342.1  tuftelin isoform X2

      UniProtKB/TrEMBL
      D3ZKZ5

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108948.1: Suppressed sequence

      Description
      NM_001108948.1: This RefSeq has been removed because currently there is insufficient support for the transcript and protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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