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    Tmigd3 transmembrane and immunoglobulin domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100363178, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmigd3provided by RGD
    Official Full Name
    transmembrane and immunoglobulin domain containing 3provided by RGD
    Primary source
    RGD:2324712
    See related
    EnsemblRapid:ENSRNOG00000043375 AllianceGenome:RGD:2324712
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in several processes, including negative regulation of NF-kappaB transcription factor activity; negative regulation of cell migration; and negative regulation of cell population proliferation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human TMIGD3 (transmembrane and immunoglobulin domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 122.0) and Spleen (RPKM 18.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmigd3 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (196027286..196103430)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (193338950..193415107)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (208478373..208557356)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene RAP1A, member of RAS oncogene family Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene RAS-related protein 1a like Neighboring gene uncharacterized LOC108350083 Neighboring gene uncharacterized LOC134485666 Neighboring gene SUB1 regulator of transcription, pseudogene 4 Neighboring gene adenosine A3 receptor Neighboring gene similar to human chromosome 1 open reading frame 162 Neighboring gene ATP synthase peripheral stalk-membrane subunit b Neighboring gene WD repeat domain 77

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression. Iyer SV, et al. Nat Commun, 2016 Nov 25. PMID 27886186, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114438

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in immune response-activating signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane and immunoglobulin domain containing 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302749.1 → NP_001289678.1  transmembrane and immunoglobulin domain containing 3 precursor

      See identical proteins and their annotated locations for NP_001289678.1

      Status: VALIDATED

      Source sequence(s)
      BC097395, FM077301, JAXUCZ010000002
      UniProtKB/TrEMBL
      F7FB47, Q4V8H0
      Related
      ENSRNOP00000068169.1, ENSRNOT00000075939.4
      Conserved Domains (1) summary
      cl11960
      Location:24 → 98
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      196027286..196103430
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017590570.3 → XP_017446059.2  transmembrane and immunoglobulin domain containing 3 isoform X2

      UniProtKB/TrEMBL
      F7FB47
      Related
      ENSRNOP00000021288.5, ENSRNOT00000021288.8

    2. XM_063281089.1 → XP_063137159.1  transmembrane and immunoglobulin domain containing 3 isoform X1

      UniProtKB/TrEMBL
      F7FB47

    3. XM_063281090.1 → XP_063137160.1  transmembrane and immunoglobulin domain containing 3 isoform X3

      UniProtKB/TrEMBL
      A6HUN7, F7FB47

    4. XM_017590568.3 → XP_017446057.1  transmembrane and immunoglobulin domain containing 3 isoform X3

      UniProtKB/TrEMBL
      A6HUN7, F7FB47
      Conserved Domains (1) summary
      cl11960
      Location:24 → 98
      Ig; Immunoglobulin domain

    5. XM_063281091.1 → XP_063137161.1  transmembrane and immunoglobulin domain containing 3 isoform X3

      UniProtKB/TrEMBL
      A6HUN7, F7FB47
    Nucleotide Protein Strain
    Heading Accession and Version

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