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    Med12l mediator complex subunit 12L [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690752, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Med12lprovided by RGD
    Official Full Name
    mediator complex subunit 12Lprovided by RGD
    Primary source
    RGD:1592212
    See related
    EnsemblRapid:ENSRNOG00000010680 AllianceGenome:RGD:1592212
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304617
    Summary
    Predicted to enable beta-catenin binding activity and transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of mediator complex. Orthologous to human MED12L (mediator complex subunit 12L). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 106.4), Brain (RPKM 60.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Med12l in Genome Data Viewer
    Location:
    2q26
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (145403318..145726317)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (143253048..143576507)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (149213134..149316569)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7a, pseudogene 21 Neighboring gene uncharacterized LOC134485737 Neighboring gene uncharacterized LOC120100831 Neighboring gene G protein-coupled receptor 171 Neighboring gene purinergic receptor P2Y14 Neighboring gene G protein-coupled receptor 87 Neighboring gene purinergic receptor P2Y13 Neighboring gene purinergic receptor P2Y12 Neighboring gene immunoglobulin superfamily, member 10 Neighboring gene activated RNA polymerase II transcriptional coactivator p15 pseudogene Neighboring gene arylacetamide deacetylase-like 2 like Neighboring gene AADACL2 family member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia. Vogl MR, et al. J Neurosci, 2013 Apr 10. PMID 23575864, Free PMC Article
    2. The Mediator complex and transcription regulation. Poss ZC, et al. Crit Rev Biochem Mol Biol, 2013 Nov-Dec. PMID 24088064, Free PMC Article
    3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 12-like protein
    Names
    mediator complex subunit 12-like
    no opposite paired repeat protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      145403318..145726317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103686.1 → XP_038959614.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X1

      Related
      ENSRNOP00000100400.1, ENSRNOT00000148788.1
      Conserved Domains (3) summary
      pfam09497
      Location:106 → 172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:1849 → 2078
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294 → 776
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

    2. XM_039103693.1 → XP_038959621.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X7

      UniProtKB/TrEMBL
      A0A0G2JV69
      Related
      ENSRNOP00000068819.3, ENSRNOT00000083504.3
      Conserved Domains (2) summary
      pfam09497
      Location:106 → 172
      Med12; Transcription mediator complex subunit Med12
      pfam12145
      Location:294 → 776
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

    3. XM_039103694.1 → XP_038959622.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X8

      UniProtKB/TrEMBL
      A0A0G2JV69
      Related
      ENSRNOP00000014471.8, ENSRNOT00000014470.9
      Conserved Domains (2) summary
      pfam09497
      Location:106 → 172
      Med12; Transcription mediator complex subunit Med12
      pfam12145
      Location:294 → 776
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

    4. XM_039103689.1 → XP_038959617.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X3

      Conserved Domains (3) summary
      pfam09497
      Location:106 → 172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:1844 → 2073
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294 → 776
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

    5. XM_039103688.1 → XP_038959616.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X2

      Conserved Domains (3) summary
      pfam09497
      Location:106 → 172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:1848 → 2077
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294 → 776
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

    6. XM_039103691.1 → XP_038959619.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X5

      UniProtKB/TrEMBL
      A0A0G2JV69, A0A0G2K5Q3
      Related
      ENSRNOP00000073514.2, ENSRNOT00000082464.3
      Conserved Domains (3) summary
      pfam09497
      Location:106 → 172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:1814 → 2043
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294 → 741
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

    7. XM_039103690.1 → XP_038959618.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X4

      Related
      ENSRNOP00000069370.2, ENSRNOT00000084020.3
      Conserved Domains (3) summary
      pfam09497
      Location:106 → 161
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:1838 → 2067
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:283 → 765
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

    8. XM_039103692.1 → XP_038959620.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X6

      UniProtKB/TrEMBL
      A0A0G2JV69
      Conserved Domains (3) summary
      pfam09497
      Location:106 → 161
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:1803 → 2032
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:283 → 730
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

    9. XM_039103696.2 → XP_038959624.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X9

      UniProtKB/TrEMBL
      A6JVK6
      Conserved Domains (1) summary
      pfam12144
      Location:967 → 1196
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain

    10. XM_063282897.1 → XP_063138967.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X9

      UniProtKB/TrEMBL
      A6JVK6

    RNA

    1. XR_005500979.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001169130.1: Suppressed sequence

      Description
      NM_001169130.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: MED12L (GeneID:116931).
    Nucleotide Protein Strain
    Heading Accession and Version

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