Eif2a eukaryotic translation initiation factor 2A [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Eif2aprovided by RGD
Full Name: eukaryotic translation initiation factor 2Aprovided by RGD
Primary source: RGD:1589591
See related: EnsemblRapid:ENSRNOG00000013393 AllianceGenome:RGD:1589591
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable nucleic acid binding activity and ribosome binding activity. Involved in response to amino acid starvation. Predicted to be located in cytoplasm. Predicted to be part of cytosolic small ribosomal subunit and eukaryotic translation initiation factor 2 complex. Biomarker of borna disease. Orthologous to human EIF2A (eukaryotic translation initiation factor 2A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 181.2), Kidney (RPKM 158.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q26

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (144911247..144944705)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (142761303..142794767)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (148722343..148755781)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that the administration of Pien Tze Huang ameliorated the severity of alcoholic and high-fat diet rats possibly by inhibiting the Hcy-induced PERK/eIF2alpha pathway.
Title: Pien Tze Huang ameliorates liver injury by inhibiting the PERK/eIF2α signaling pathway in alcohol and high-fat diet rats.
AS-IV may attenuate inflammatory responses by disrupting the crosstalk between autophagy and the PERK-eIF2alpha pathway and may be an ideal agent for treating inflammatory pulmonary diseases.
Title: Astragaloside-IV Alleviates Heat-Induced Inflammation by Inhibiting Endoplasmic Reticulum Stress and Autophagy.
We suggest from these data that AMC-01 and its derivative compounds can be used as chemical probes in future studies of the role of eIF2-alpha in protein synthesis-related cell physiology.
Title: The small molecule '1-(4-biphenylylcarbonyl)-4-(5-bromo-2-methoxybenzyl) piperazine oxalate' and its derivatives regulate global protein synthesis by inactivating eukaryotic translation initiation factor 2-alpha.
In an endoplasmic reticulum-stressed rat brain model, eif2a is phosphorylated via the PERK signal pathway.
Title: α-Synuclein is involved in manganese-induced ER stress via PERK signal pathway in organotypic brain slice cultures.
Autophagy induced by (125)I radiation was involved in endoplasmic reticulum stress and mainly dependent on PERK-eIF2alpha pathway.
Title: Regulation of autophagy via PERK-eIF2α effectively relieve the radiation myelitis induced by iodine-125.
hyperoxia-induced suppression of mRNA translation in the newborn lung is accompanied by increased phosphorylation of eIF2alpha in the epithelium
Title: Hyperoxia inhibits protein synthesis and increases eIF2α phosphorylation in the newborn rat lung.

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General gene information

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Markers

RH144657 (e-PCR)
- UniSTS:233902

RH132730 (e-PCR)
- UniSTS:216013

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA binding	ISO Inferred from Sequence Orthology more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within SREBP signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in response to amino acid starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in ribosome assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within translation	ISO Inferred from Sequence Orthology more info
involved_in translational initiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of cytosolic small ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 2 complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399818.1 → NP_001386747.1 eukaryotic translation initiation factor 2A

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A8I6GH40, A6JVI7, D3ZUV3

Related

ENSRNOP00000018022.8, ENSRNOT00000018022.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

144911247..144944705

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063282412.1 → XP_063138482.1 eukaryotic translation initiation factor 2A isoform X1

UniProtKB/TrEMBL

A6JVI8

RNA

XR_005500352.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001109339.1: Suppressed sequence

Description

NM_001109339.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.