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    Wdr83 WD repeat domain 83 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288924, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Wdr83provided by RGD
    Official Full Name
    WD repeat domain 83provided by RGD
    Primary source
    RGD:1306947
    See related
    EnsemblRapid:ENSRNOG00000004287 AllianceGenome:RGD:1306947
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Morg1; RGD1306947
    Summary
    Predicted to be involved in mRNA splicing, via spliceosome. Predicted to act upstream of or within several processes, including neural tube closure; placenta blood vessel development; and regulation of canonical NF-kappaB signal transduction. Located in cytoplasm. Orthologous to human WDR83 (WD repeat domain 83). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 107.4), Spleen (RPKM 81.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wdr83 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (39981890..39987443)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (23076948..23082569)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (26188644..26194193, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene mannosidase, alpha, class 2B, member 1 Neighboring gene WD repeat domain 83 opposite strand Neighboring gene deoxyhypusine synthase Neighboring gene G protein subunit gamma 14 Neighboring gene F-box and WD repeat domain containing 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Morg1 heterozygous deficiency ameliorates hypoxia-induced acute renal injury. Loeffler I, et al. Am J Physiol Renal Physiol, 2015 Mar 15. PMID 25550320
    2. The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3). Hopfer U, et al. J Biol Chem, 2006 Mar 31. PMID 16407229
    3. Advanced glycated end-products affect HIF-transcriptional activity in renal cells. Bondeva T, et al. Mol Endocrinol, 2013 Nov. PMID 24030251, Free PMC Article
    4. MORG1(+/-) mice are protected from histological renal damage and inflammation in a murine model of endotoxemia. Bondeva T, et al. BMC Nephrol, 2018 Feb 5. PMID 29402223, Free PMC Article
    5. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. Jurica MS, et al. RNA, 2002 Apr. PMID 11991638, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in RNA splicing, via transesterification reactions ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inflammatory response to wounding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within inflammatory response to wounding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neural tube closure IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neural tube closure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in placenta blood vessel development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within placenta blood vessel development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to wounding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat domain-containing protein 83
    Names
    MAPK organizer 1
    WD repeat protein Morg1
    mitogen-activated protein kinase organizer 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047847.1 → NP_001041312.1  WD repeat domain-containing protein 83

      See identical proteins and their annotated locations for NP_001041312.1

      Status: PROVISIONAL

      Source sequence(s)
      AY940050
      UniProtKB/Swiss-Prot
      Q5BLX8
      UniProtKB/TrEMBL
      A6IY27, G3V6J9
      Related
      ENSRNOP00000005917.3, ENSRNOT00000005917.7
      Conserved Domains (3) summary
      COG2319
      Location:11 → 311
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:18 → 304
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:30 → 65
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      39981890..39987443
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097536.2 → XP_038953464.1  WD repeat domain-containing protein 83 isoform X1

      UniProtKB/TrEMBL
      A6IY27, G3V6J9
      Conserved Domains (2) summary
      cd00200
      Location:18 → 264
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:30 → 65
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BLX8.1 GenPept UniProtKB/Swiss-Prot:Q5BLX8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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