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    Abcc12 ATP binding cassette subfamily C member 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291923, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Abcc12provided by RGD
    Official Full Name
    ATP binding cassette subfamily C member 12provided by RGD
    Primary source
    RGD:735100
    See related
    EnsemblRapid:ENSRNOG00000015666 AllianceGenome:RGD:735100
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in endoplasmic reticulum. Predicted to be active in membrane. Orthologous to human ABCC12 (ATP binding cassette subfamily C member 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 59.8) See more
    Orthologs
    human all
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    Genomic context

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    See Abcc12 in Genome Data Viewer
    Location:
    19p11
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (36722550..36798868)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (20549298..20621991)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (21541324..21612757)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene siah E3 ubiquitin protein ligase 1 Neighboring gene lon peptidase 2, peroxisomal Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134483622 Neighboring gene nucleophosmin 1, pseudogene 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of the mouse Abcc12 gene and its transcript encoding an ATP-binding cassette transporter, an orthologue of human ABCC12. Shimizu H, et al. Gene, 2003 May 22. PMID 12801629
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-binding cassette sub-family C member 12
    Names
    ATP-binding cassette transporter sub-family C member 12
    ATP-binding cassette, sub-family C (CFTR/MRP), member 12
    ATP-binding cassette, subfamily C (CFTR/MRP), member 12
    multidrug resistance-associated protein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199377.1 → NP_955409.1  ATP-binding cassette sub-family C member 12

      See identical proteins and their annotated locations for NP_955409.1

      Status: PROVISIONAL

      Source sequence(s)
      AY188179
      UniProtKB/Swiss-Prot
      Q6Y305, Q6Y306
      UniProtKB/TrEMBL
      D3ZIZ6
      Related
      ENSRNOP00000044842.2, ENSRNOT00000042077.4
      Conserved Domains (4) summary
      cd03244
      Location:1125 → 1345
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:487 → 679
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      TIGR01271
      Location:44 → 1343
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      cl00549
      Location:795 → 1077
      ABC_membrane; ABC transporter transmembrane region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      36722550..36798868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008772375.4 → XP_008770597.1  ATP-binding cassette sub-family C member 12 isoform X1

      UniProtKB/TrEMBL
      D3ZIZ6
      Conserved Domains (4) summary
      cd03244
      Location:1132 → 1357
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:487 → 686
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      TIGR01271
      Location:44 → 1348
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      cl00549
      Location:802 → 1084
      ABC_membrane; ABC transporter transmembrane region

    2. XM_008772376.4 → XP_008770598.1  ATP-binding cassette sub-family C member 12 isoform X2

      UniProtKB/TrEMBL
      D3ZIZ6
      Conserved Domains (4) summary
      cd03244
      Location:1132 → 1352
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:487 → 686
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      TIGR01271
      Location:44 → 1350
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      cl00549
      Location:802 → 1084
      ABC_membrane; ABC transporter transmembrane region

    3. XM_039097573.2 → XP_038953501.1  ATP-binding cassette sub-family C member 12 isoform X4

      UniProtKB/TrEMBL
      D3ZIZ6
      Conserved Domains (1) summary
      TIGR00957
      Location:43 → 1358
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    4. XM_006255241.5 → XP_006255303.1  ATP-binding cassette sub-family C member 12 isoform X3

      UniProtKB/TrEMBL
      D3ZIZ6
      Related
      ENSRNOP00000021095.5, ENSRNOT00000021095.7
      Conserved Domains (4) summary
      cd03244
      Location:1125 → 1350
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:487 → 679
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      TIGR01271
      Location:44 → 1341
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      cl00549
      Location:795 → 1077
      ABC_membrane; ABC transporter transmembrane region

    5. XM_039097576.1 → XP_038953504.1  ATP-binding cassette sub-family C member 12 isoform X6

      Conserved Domains (1) summary
      TIGR00957
      Location:43 → 971
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    6. XM_039097575.2 → XP_038953503.1  ATP-binding cassette sub-family C member 12 isoform X6

      Conserved Domains (1) summary
      TIGR00957
      Location:43 → 971
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    7. XM_063277869.1 → XP_063133939.1  ATP-binding cassette sub-family C member 12 isoform X5

      UniProtKB/TrEMBL
      A6KDC5

    8. XM_063277870.1 → XP_063133940.1  ATP-binding cassette sub-family C member 12 isoform X7

      UniProtKB/TrEMBL
      A6KDC5

    9. XM_039097577.2 → XP_038953505.1  ATP-binding cassette sub-family C member 12 isoform X8

      UniProtKB/TrEMBL
      A6KDC5
      Conserved Domains (1) summary
      TIGR00957
      Location:62 → 943
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    RNA

    1. XR_005496627.2 RNA Sequence

    2. XR_005496628.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6Y306.1 GenPept UniProtKB/Swiss-Prot:Q6Y306

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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