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    Acbd5 acyl-CoA binding domain containing 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307170, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acbd5provided by RGD
    Official Full Name
    acyl-CoA binding domain containing 5provided by RGD
    Primary source
    RGD:1309411
    See related
    EnsemblRapid:ENSRNOG00000017642 AllianceGenome:RGD:1309411
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable fatty-acyl-CoA binding activity. Predicted to be involved in fatty acid metabolic process and pexophagy. Predicted to be located in nucleoplasm. Predicted to be active in peroxisome. Human ortholog(s) of this gene implicated in retinal dystrophy with leukodystrophy. Orthologous to human ACBD5 (acyl-CoA binding domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 205.2), Liver (RPKM 193.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Acbd5 in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (90114250..90156286)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (85206178..85248909)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (89882465..89923982, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene abl-interactor 1 Neighboring gene ribosomal protein S26, pseudogene 1 Neighboring gene microtubule associated serine/threonine kinase-like Neighboring gene YME1-like 1 ATPase Neighboring gene POTE ankyrin domain family, member C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Peroxisomal Atg37 binds Atg30 or palmitoyl-CoA to regulate phagophore formation during pexophagy. Nazarko TY, et al. J Cell Biol, 2014 Feb 17. PMID 24535825, Free PMC Article
    2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables fatty-acyl-CoA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty-acyl-CoA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pexophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pexophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    acyl-CoA-binding domain-containing protein 5
    Names
    acyl-Coenzyme A binding domain containing 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077635.3 → NP_001071103.1  acyl-CoA-binding domain-containing protein 5 isoform 1

      See identical proteins and their annotated locations for NP_001071103.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      B1H213
      Conserved Domains (1) summary
      cd00435
      Location:9 → 96
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    2. NM_001399254.1 → NP_001386183.1  acyl-CoA-binding domain-containing protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      B1H213
      Related
      ENSRNOP00000068154.2, ENSRNOT00000076964.3
      Conserved Domains (1) summary
      cd00435
      Location:45 → 132
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      90114250..90156286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095812.2 → XP_038951740.1  acyl-CoA-binding domain-containing protein 5 isoform X11

      UniProtKB/TrEMBL
      B1H213
      Conserved Domains (1) summary
      cd00435
      Location:9 → 96
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    2. XM_063276510.1 → XP_063132580.1  acyl-CoA-binding domain-containing protein 5 isoform X16

      UniProtKB/TrEMBL
      B1H213

    3. XM_039095813.2 → XP_038951741.1  acyl-CoA-binding domain-containing protein 5 isoform X14

      UniProtKB/TrEMBL
      B1H213
      Conserved Domains (1) summary
      cd00435
      Location:9 → 96
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    4. XM_063276511.1 → XP_063132581.1  acyl-CoA-binding domain-containing protein 5 isoform X17

      UniProtKB/TrEMBL
      A0A096MJJ6, A6KRZ4, B1H213

    5. XM_063276516.1 → XP_063132586.1  acyl-CoA-binding domain-containing protein 5 isoform X25

      UniProtKB/TrEMBL
      B1H213

    6. XM_063276519.1 → XP_063132589.1  acyl-CoA-binding domain-containing protein 5 isoform X28

      UniProtKB/TrEMBL
      B1H213

    7. XM_006254345.5 → XP_006254407.1  acyl-CoA-binding domain-containing protein 5 isoform X8

      See identical proteins and their annotated locations for XP_006254407.1

      UniProtKB/Swiss-Prot
      A0FKI6, A0FKI7, Q3T1K2
      UniProtKB/TrEMBL
      B1H213
      Related
      ENSRNOP00000076762.2, ENSRNOT00000093822.2
      Conserved Domains (1) summary
      cd00435
      Location:45 → 132
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    8. XM_006254343.3 → XP_006254405.1  acyl-CoA-binding domain-containing protein 5 isoform X5

      UniProtKB/TrEMBL
      A0A8I5Y939, B1H213
      Conserved Domains (1) summary
      cd00435
      Location:45 → 132
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    9. XM_063276512.1 → XP_063132582.1  acyl-CoA-binding domain-containing protein 5 isoform X23

      UniProtKB/TrEMBL
      B1H213

    10. XM_017600582.3 → XP_017456071.1  acyl-CoA-binding domain-containing protein 5 isoform X20

      UniProtKB/TrEMBL
      B1H213

    11. XM_006254351.5 → XP_006254413.1  acyl-CoA-binding domain-containing protein 5 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AH07, B1H213
      Related
      ENSRNOP00000092017.1, ENSRNOT00000104691.2
      Conserved Domains (1) summary
      cd00435
      Location:45 → 132
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    12. XM_017600577.3 → XP_017456066.1  acyl-CoA-binding domain-containing protein 5 isoform X2

      UniProtKB/TrEMBL
      B1H213

    13. XM_063276507.1 → XP_063132577.1  acyl-CoA-binding domain-containing protein 5 isoform X12

      UniProtKB/TrEMBL
      B1H213
      Related
      ENSRNOP00000107708.1, ENSRNOT00000130190.1

    14. XM_063276508.1 → XP_063132578.1  acyl-CoA-binding domain-containing protein 5 isoform X13

      UniProtKB/TrEMBL
      B1H213

    15. XM_039095811.2 → XP_038951739.1  acyl-CoA-binding domain-containing protein 5 isoform X9

      UniProtKB/TrEMBL
      B1H213
      Conserved Domains (1) summary
      cd00435
      Location:45 → 132
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    16. XM_017600579.3 → XP_017456068.1  acyl-CoA-binding domain-containing protein 5 isoform X7

      UniProtKB/TrEMBL
      B1H213

    17. XM_063276505.1 → XP_063132575.1  acyl-CoA-binding domain-containing protein 5 isoform X10

      UniProtKB/TrEMBL
      B1H213

    18. XM_017600575.3 → XP_017456064.1  acyl-CoA-binding domain-containing protein 5 isoform X1

      UniProtKB/TrEMBL
      B1H213

    19. XM_063276517.1 → XP_063132587.1  acyl-CoA-binding domain-containing protein 5 isoform X26

    20. XM_063276518.1 → XP_063132588.1  acyl-CoA-binding domain-containing protein 5 isoform X27

    21. XM_017600581.3 → XP_017456070.1  acyl-CoA-binding domain-containing protein 5 isoform X18

      UniProtKB/TrEMBL
      B1H213

    22. XM_039095815.2 → XP_038951743.1  acyl-CoA-binding domain-containing protein 5 isoform X19

      UniProtKB/TrEMBL
      B1H213
      Conserved Domains (1) summary
      cd00435
      Location:45 → 132
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    23. XM_039095817.2 → XP_038951745.1  acyl-CoA-binding domain-containing protein 5 isoform X22

      UniProtKB/TrEMBL
      B1H213
      Conserved Domains (1) summary
      cd00435
      Location:45 → 132
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    24. XM_039095816.2 → XP_038951744.1  acyl-CoA-binding domain-containing protein 5 isoform X21

      UniProtKB/TrEMBL
      B1H213
      Conserved Domains (1) summary
      cd00435
      Location:45 → 132
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    25. XM_063276514.1 → XP_063132584.1  acyl-CoA-binding domain-containing protein 5 isoform X24

    26. XM_063276504.1 → XP_063132574.1  acyl-CoA-binding domain-containing protein 5 isoform X6

      UniProtKB/TrEMBL
      B1H213

    27. XM_063276513.1 → XP_063132583.1  acyl-CoA-binding domain-containing protein 5 isoform X24

    28. XM_039095810.2 → XP_038951738.1  acyl-CoA-binding domain-containing protein 5 isoform X3

      UniProtKB/TrEMBL
      A6KRZ3, B1H213
      Conserved Domains (1) summary
      cd00435
      Location:45 → 132
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    29. XM_063276509.1 → XP_063132579.1  acyl-CoA-binding domain-containing protein 5 isoform X15

      UniProtKB/TrEMBL
      B1H213
      Related
      ENSRNOP00000112606.1, ENSRNOT00000138217.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0FKI7.1 GenPept UniProtKB/Swiss-Prot:A0FKI7

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