Igfbp4 insulin-like growth factor binding protein 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Igfbp4provided by RGD
Official Full Name: insulin-like growth factor binding protein 4provided by RGD
Primary source: RGD:2875
See related: EnsemblRapid:ENSRNOG00000010635 AllianceGenome:RGD:2875
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: IBP4; IGF-BP4
Summary: Predicted to enable insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in response to organic cyclic compound. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human IGFBP4 (insulin like growth factor binding protein 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 1872.3), Lung (RPKM 361.6) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (84491471..84503487)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (83995253..84007272)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (86950555..86962563)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Specific cleavage of IGFBP-4 by papp-a in nervous tissue.
Title: Specific cleavage of IGFBP-4 by papp-a in nervous tissue.
Insulin-like growth factor binding protein 4 loaded electrospun membrane ameliorating tendon injury by promoting retention of IGF-1.
Title: Insulin-like growth factor binding protein 4 loaded electrospun membrane ameliorating tendon injury by promoting retention of IGF-1.
IGFBP-4 Proteolysis by PAPP-A in a Primary Culture of Rat Neonatal Cardiomyocytes under Normal and Hypertrophic Conditions.
Title: IGFBP-4 Proteolysis by PAPP-A in a Primary Culture of Rat Neonatal Cardiomyocytes under Normal and Hypertrophic Conditions.
IGFBP4 overexpression impaired BMP2-induced osteogenic differentiation potential of young MSCs, whereas IGFBP4 knockdown restored the osteogenic potency of aged MSCs. Moreover, IGFBP4 knockdown stimulated the activation of Erk and Smad by increasing phosphorylation.
Title: Age-Related Insulin-Like Growth Factor Binding Protein-4 Overexpression Inhibits Osteogenic Differentiation of Rat Mesenchymal Stem Cells.
various inflammatory insults decrease muscle IGFBP-5 mRNA, without altering IGFBP-4, by a TNF-dependent glucocorticoid-independent mechanism.
Title: Sepsis and inflammatory insults downregulate IGFBP-5, but not IGFBP-4, in skeletal muscle via a TNF-dependent mechanism.
The temporal expression pattern of IGFBP-4 in the embryonic brain suggests an important role of IGFBP-4 in regulating differentiation of neural stem cells
Title: Temporal expression patterns of insulin-like growth factor binding protein-4 in the embryonic and postnatal rat brain.
IGFBP-4 expression is induced in hepatoma cells by the dioxin 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Title: TCDD induces the expression of insulin-like growth factor binding protein 4 in 5L rat hepatoma cells: a cautionary tale of the use of this cell line in studies on dioxin toxicity.
knockdown results in decreased differentiation potential of mesenchymal stromal cells
Title: GATA-4 promotes myocardial transdifferentiation of mesenchymal stromal cells via up-regulating IGFBP-4.
Overexpression of pulmonary IGFBP-4 during the later stages of lung development may contribute to pulmonary hypoplasia
Title: IGFBP-4 gene overexpression in the nitrofen-induced hypoplastic lung.
five different glycosylation isoforms of the protein
Title: Identification of N-linked oligosaccharides of rat insulin-like growth factor binding protein-4.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Igfbp4 (e-PCR), detects polymorphism
- UniSTS:472858

RH140035 (e-PCR)
- UniSTS:222117

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables insulin-like growth factor I binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor II binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor binding	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of glucose metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within type B pancreatic cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: insulin-like growth factor-binding protein 4

Names: IBP-4; IGF-binding protein 4; IGFBP-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004274.2 → NP_001004274.1 insulin-like growth factor-binding protein 4 precursor

See identical proteins and their annotated locations for NP_001004274.1

Status: PROVISIONAL

Source sequence(s)

BC098750

UniProtKB/Swiss-Prot

P21744, Q68J74

UniProtKB/TrEMBL

A6HIW3, A6HIW4

Related

ENSRNOP00000014153.5, ENSRNOT00000014153.9

Conserved Domains (2) summary

smart00121
Location:25 → 101

IB; Insulin growth factor-binding protein homologues

pfam00086
Location:170 → 245

Thyroglobulin_1; Thyroglobulin type-1 repeat