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    Ccdc63 coiled-coil domain containing 63 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304484, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccdc63provided by RGD
    Official Full Name
    coiled-coil domain containing 63provided by RGD
    Primary source
    RGD:1562334
    See related
    EnsemblRapid:ENSRNOG00000034266 AllianceGenome:RGD:1562334
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in cilium movement; outer dynein arm assembly; and spermatid development. Predicted to be active in axoneme. Orthologous to human CCDC63 (coiled-coil domain containing 63). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 163.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccdc63 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (40085146..40113820)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (34424388..34453080)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (39905120..39950719)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene tectonic family member 1 Neighboring gene hydrogen voltage-gated channel 1 Neighboring gene protein phosphatase 1 catalytic subunit gamma Neighboring gene uncharacterized LOC120095977 Neighboring gene 5S ribosomal RNA Neighboring gene myosin light chain 2 Neighboring gene uncharacterized LOC120095979

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines Identified Ccdc63 as Essential for Spermiogenesis. Young SA, et al. Int J Mol Sci, 2015 Oct 16. PMID 26501274, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114454

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cilium movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in outer dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatid development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 63

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025665.1 → NP_001020836.1  coiled-coil domain-containing protein 63

      See identical proteins and their annotated locations for NP_001020836.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097409
      UniProtKB/Swiss-Prot
      Q4V8F7
      UniProtKB/TrEMBL
      F1LTP5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      40085146..40113820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089459.2 → XP_038945387.1  coiled-coil domain-containing protein 63 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZZ40, F1LTP5
      Conserved Domains (1) summary
      TIGR02168
      Location:164 → 437
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_039089457.2 → XP_038945385.1  coiled-coil domain-containing protein 63 isoform X1

      UniProtKB/TrEMBL
      F1LTP5
      Related
      ENSRNOP00000083028.2, ENSRNOT00000119110.2
      Conserved Domains (1) summary
      TIGR02168
      Location:164 → 437
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. XM_039089462.2 → XP_038945390.2  coiled-coil domain-containing protein 63 isoform X8

    4. XM_039089460.2 → XP_038945388.1  coiled-coil domain-containing protein 63 isoform X5

      UniProtKB/TrEMBL
      F1LTP5
      Conserved Domains (1) summary
      TIGR02168
      Location:164 → 437
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    5. XM_039089461.2 → XP_038945389.1  coiled-coil domain-containing protein 63 isoform X7

      Conserved Domains (1) summary
      TIGR02168
      Location:164 → 437
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    6. XM_063271318.1 → XP_063127388.1  coiled-coil domain-containing protein 63 isoform X3

      UniProtKB/Swiss-Prot
      Q4V8F7
      UniProtKB/TrEMBL
      F1LTP5

    7. XM_063271324.1 → XP_063127394.1  coiled-coil domain-containing protein 63 isoform X6

      UniProtKB/TrEMBL
      F1LTP5

    8. XM_063271321.1 → XP_063127391.1  coiled-coil domain-containing protein 63 isoform X4

      UniProtKB/TrEMBL
      F1LTP5

    9. XM_063271316.1 → XP_063127386.1  coiled-coil domain-containing protein 63 isoform X3

      UniProtKB/Swiss-Prot
      Q4V8F7
      UniProtKB/TrEMBL
      F1LTP5

    10. XM_063271323.1 → XP_063127393.1  coiled-coil domain-containing protein 63 isoform X6

      UniProtKB/TrEMBL
      F1LTP5
      Related
      ENSRNOP00000043589.7, ENSRNOT00000046604.7

    11. XM_063271319.1 → XP_063127389.1  coiled-coil domain-containing protein 63 isoform X4

      UniProtKB/TrEMBL
      F1LTP5

    12. XM_063271325.1 → XP_063127395.1  coiled-coil domain-containing protein 63 isoform X9

    13. XM_063271322.1 → XP_063127392.1  coiled-coil domain-containing protein 63 isoform X4

      UniProtKB/TrEMBL
      F1LTP5

    14. XM_063271320.1 → XP_063127390.1  coiled-coil domain-containing protein 63 isoform X4

      UniProtKB/TrEMBL
      F1LTP5

    15. XM_063271317.1 → XP_063127387.1  coiled-coil domain-containing protein 63 isoform X3

      UniProtKB/Swiss-Prot
      Q4V8F7
      UniProtKB/TrEMBL
      F1LTP5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V8F7.1 GenPept UniProtKB/Swiss-Prot:Q4V8F7

    Gene LinkOut

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    Chemical Information
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    Research Materials