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    Map3k13 mitogen-activated protein kinase kinase kinase 13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303823, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Map3k13provided by RGD
    Official Full Name
    mitogen-activated protein kinase kinase kinase 13provided by RGD
    Primary source
    RGD:1561227
    See related
    EnsemblRapid:ENSRNOG00000025423 AllianceGenome:RGD:1561227
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including IkappaB kinase complex binding activity; JUN kinase kinase kinase activity; and protein homodimerization activity. Predicted to be involved in several processes, including MAPK cascade; positive regulation of cell projection organization; and protein phosphorylation. Predicted to be located in membrane. Predicted to be active in cytoplasm. Orthologous to human MAP3K13 (mitogen-activated protein kinase kinase kinase 13). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 120.1), Liver (RPKM 97.0) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Map3k13 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (92596436..92741717, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (79094087..79235181, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (82744391..82938357, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene lipase H Neighboring gene transmembrane protein 41a Neighboring gene small ubiquitin-related modifier 2-like Neighboring gene enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase Neighboring gene uncharacterized LOC134481029

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Integrated genomic profiling and modelling for risk stratification in patients with advanced oesophagogastric adenocarcinoma. Hao D, et al. Gut, 2021 Nov. PMID 33334899, Free PMC Article
    2. Identification and characterization of functional domains in a mixed lineage kinase LZK. Ikeda A, et al. FEBS Lett, 2001 Jan 19. PMID 11163770
    3. Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain. Sakuma H, et al. J Biol Chem, 1997 Nov 7. PMID 9353328
    4. Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons. Chen M, et al. Sci Rep, 2016 Aug 11. PMID 27511108, Free PMC Article
    5. Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway. Ikeda A, et al. J Biochem, 2001 Dec. PMID 11726277

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables IkappaB kinase complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MAP kinase kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of branching morphogenesis of a nerve ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection arborization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of macromolecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of primary metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase 13
    Names
    leucine zipper-bearing kinase
    NP_001014000.2
    XP_017453465.1
    XP_063126552.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013978.2 → NP_001014000.2  mitogen-activated protein kinase kinase kinase 13

      See identical proteins and their annotated locations for NP_001014000.2

      Status: PROVISIONAL

      Source sequence(s)
      CH473999
      UniProtKB/TrEMBL
      A6JS67, F7FMK8
      Related
      ENSRNOP00000038786.6, ENSRNOT00000035945.8
      Conserved Domains (2) summary
      smart00221
      Location:168 → 402
      STYKc; Protein kinase; unclassified specificity
      cd14059
      Location:174 → 410
      STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      92596436..92741717 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270482.1 → XP_063126552.1  mitogen-activated protein kinase kinase kinase 13 isoform X1

      UniProtKB/TrEMBL
      A6JS67, F7FMK8

    2. XM_017597976.3 → XP_017453465.1  mitogen-activated protein kinase kinase kinase 13 isoform X1

      UniProtKB/TrEMBL
      A6JS67, F7FMK8
      Conserved Domains (2) summary
      smart00221
      Location:168 → 402
      STYKc; Protein kinase; unclassified specificity
      cd14059
      Location:174 → 410
      STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
    Nucleotide Protein Strain
    Heading Accession and Version

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