Nme1 NME/NM23 nucleoside diphosphate kinase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nme1provided by RGD
Official Full Name: NME/NM23 nucleoside diphosphate kinase 1provided by RGD
Primary source: RGD:70497
See related: EnsemblRapid:ENSRNOG00000002693 AllianceGenome:RGD:70497
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including DNA binding activity; gamma-tubulin binding activity; and nucleoside diphosphate kinase activity. Involved in several processes, including GTP biosynthetic process; cellular response to glucose stimulus; and response to testosterone. Located in cytoskeleton; mitochondrial outer membrane; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in neuroblastoma; ovary epithelial cancer; and teratoma. Orthologous to human NME1 (NME/NM23 nucleoside diphosphate kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 449.2), Thymus (RPKM 294.5) and 9 other tissues See more
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Genomic context

Location:: 10q26

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (79403939..79426620, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (78907036..78929659, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (81657152..81666542, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of metastasis suppressor NME1 by a key metabolic cofactor coenzyme A.
Title: Regulation of metastasis suppressor NME1 by a key metabolic cofactor coenzyme A.
NDPKA up-regulation increased neuronal survival in cortical neurons from cerebral ischemia models.
Title: Erythropoietin increases neuronal NDPKA expression, and NDPKA up-regulation as well as exogenous application protects cortical neurons from in vitro ischemia-related insults.
data suggested that NME1 acts as a switcher or reprogramming factor which involves in oligodentrocyte versus neuron cell fate specification in vitro
Title: Nucleoside diphosphate kinase Nm23-M1 involves in oligodendroglial versus neuronal cell fate decision in vitro.
Down-regulation of expression and function of Nme1 in insulin-secreting beta-cells under in vitro conditions of glucolipotoxicity is reported.
Title: Down-regulation of expression and function of nucleoside diphosphate kinase in insulin-secreting beta-cells under in vitro conditions of glucolipotoxicity.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3'-5' exonuclease activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables DNA nuclease activity	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables gamma-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables intermediate filament binding	IPI Inferred from Physical Interaction more info	PubMed
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables nucleoside diphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside diphosphate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleoside diphosphate kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosomal small subunit binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in CTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in DNA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in GTP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in GTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within lactation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mammary gland development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of myeloid leukocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to amine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in intermediate filament	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nucleoside diphosphate kinase A

Names: NDK A; NDP kinase A; NDP kinase beta; expressed in non-metastatic cells 1, protein (NM23A) (nucleoside diphosphate kinase); metastasis inhibition factor NM23; non-metastatic cells 1, protein (NM23A) expressed in; nucloside diphosphate kinase; tumor metastatic process-associated protein

NP_612557.1

EC 2.7.4.6

XP_017452467.1

EC 2.7.4.6

XP_017452468.1

EC 2.7.4.6

XP_038941085.1

EC 2.7.4.6

XP_038941086.1

EC 2.7.4.6

XP_063124445.1

EC 2.7.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138548.2 → NP_612557.1 nucleoside diphosphate kinase A

See identical proteins and their annotated locations for NP_612557.1

Status: PROVISIONAL

Source sequence(s)

D13374

UniProtKB/Swiss-Prot

Q05982

UniProtKB/TrEMBL

A6HI35

Related

ENSRNOP00000083790.1, ENSRNOT00000112785.2

Conserved Domains (1) summary

PTZ00093
Location:3 → 151

PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

79403939..79426620 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085157.2 → XP_038941085.1 nucleoside diphosphate kinase A isoform X1

UniProtKB/Swiss-Prot

Q05982

UniProtKB/TrEMBL

A6HI35

Conserved Domains (1) summary

PTZ00093
Location:3 → 151

PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional
XM_063268375.1 → XP_063124445.1 nucleoside diphosphate kinase A isoform X1

UniProtKB/Swiss-Prot

Q05982

UniProtKB/TrEMBL

A6HI35
XM_039085158.2 → XP_038941086.1 nucleoside diphosphate kinase A isoform X1

UniProtKB/Swiss-Prot

Q05982

UniProtKB/TrEMBL

A6HI35

Conserved Domains (1) summary

PTZ00093
Location:3 → 151

PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional
XM_017596978.3 → XP_017452467.1 nucleoside diphosphate kinase A isoform X1

UniProtKB/Swiss-Prot

Q05982

UniProtKB/TrEMBL

A6HI35

Conserved Domains (1) summary

PTZ00093
Location:3 → 151

PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional
XM_017596979.3 → XP_017452468.1 nucleoside diphosphate kinase A isoform X1

UniProtKB/Swiss-Prot

Q05982

UniProtKB/TrEMBL

A6HI35

Conserved Domains (1) summary

PTZ00093
Location:3 → 151

PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional