Slco2b1 solute carrier organic anion transporter family, member 2b1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slco2b1provided by RGD
Official Full Name: solute carrier organic anion transporter family, member 2b1provided by RGD
Primary source: RGD:621391
See related: EnsemblRapid:ENSRNOG00000017976 AllianceGenome:RGD:621391
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: moat1; OATP2B1; Slc21a9
Summary: Enables bile acid transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Involved in bile acid and bile salt transport; liver development; and sodium-independent icosanoid transport. Located in apical plasma membrane. Orthologous to human SLCO2B1 (solute carrier organic anion transporter family member 2B1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 222.4), Thymus (RPKM 116.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (163371410..163419412, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (153959288..154007294, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (164623313..164671612, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Influence of Slco2b1-knockout and SLCO2B1-humanization on coproporphyrin I and III levels in rats.
Title: Influence of Slco2b1-knockout and SLCO2B1-humanization on coproporphyrin I and III levels in rats.
Differences in transport function of the human and rat orthologue of the Organic Anion Transporting Polypeptide 2B1 (OATP2B1).
Title: Differences in transport function of the human and rat orthologue of the Organic Anion Transporting Polypeptide 2B1 (OATP2B1).
Downregulated expression of organic anion transporting polypeptide (Oatp) 2b1 in the small intestine of rats with acute kidney injury.
Title: Downregulated expression of organic anion transporting polypeptide (Oatp) 2b1 in the small intestine of rats with acute kidney injury.
Oatp1a1 and Oatp2b1 expression levels are decreased by intestinal ischemia reperfusion.
Title: Intestinal ischemia-reperfusion suppresses biliary excretion of hepatic organic anion transporting polypeptides substrate.
Gene expression of OATP2B1 in spleen, kidney, and small intestine of rats with dampness pattern was lower than that in normal rats.
Title: Effect of polypeptide 2B1 on condition of dampness pattern in rats in terms of traditional Chinese medicine.
The statin transporters Oatp1a4 and Oatp2b1 are expressed in rat skeletal myofibres, but not in satellite cells, fibroblasts or in L6 myoblasts
Title: Involvement of organic anion transporting polypeptides in the toxicity of hydrophilic pravastatin and lipophilic fluvastatin in rat skeletal myofibres.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables bile acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables bile acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic anion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables sodium-independent organic anion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium-independent organic anion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium-independent organic anion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables sodium-independent organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in bile acid and bile salt transport	IDA Inferred from Direct Assay more info	PubMed
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in organic anion transport	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin transport	IEA Inferred from Electronic Annotation more info
involved_in sodium-independent icosanoid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium-independent organic anion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier organic anion transporter family member 2B1

Names: multispecific organic anion transporter 1; organic anion transporter moatp1; organic anion transporting polypeptide 2B1; solute carrier family 21 (organic anion transporter), member 9; solute carrier family 21 member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080786.2 → NP_542964.1 solute carrier organic anion transporter family member 2B1

See identical proteins and their annotated locations for NP_542964.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q9JHI3

UniProtKB/TrEMBL

A0A0G2K880

Conserved Domains (3) summary

cd06174
Location:48 → 290

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

cd01330
Location:473 → 530

KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...

pfam03137
Location:42 → 635

OATP; Organic Anion Transporter Polypeptide (OATP) family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

163371410..163419412 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063270951.1 → XP_063127021.1 solute carrier organic anion transporter family member 2B1 isoform X4

UniProtKB/TrEMBL

A0A0G2K880
XM_063270987.1 → XP_063127057.1 solute carrier organic anion transporter family member 2B1 isoform X7
XM_063270894.1 → XP_063126964.1 solute carrier organic anion transporter family member 2B1 isoform X2

UniProtKB/TrEMBL

A0A0G2K880
XM_063270974.1 → XP_063127044.1 solute carrier organic anion transporter family member 2B1 isoform X6
XM_006229721.5 → XP_006229783.1 solute carrier organic anion transporter family member 2B1 isoform X1

See identical proteins and their annotated locations for XP_006229783.1

UniProtKB/TrEMBL

A0A0G2K880, A0A8I6AV99, A6I6J4

Related

ENSRNOP00000097657.1, ENSRNOT00000095615.2

Conserved Domains (3) summary

cd06174
Location:58 → 301

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

cd01330
Location:484 → 541

KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...

pfam03137
Location:52 → 646

OATP; Organic Anion Transporter Polypeptide (OATP) family
XM_006229724.5 → XP_006229786.1 solute carrier organic anion transporter family member 2B1 isoform X3

See identical proteins and their annotated locations for XP_006229786.1

UniProtKB/TrEMBL

A0A0G2K880, A0A8L2QE88, A6I6J7

Related

ENSRNOP00000024281.6, ENSRNOT00000024281.7

Conserved Domains (3) summary

cd06174
Location:48 → 291

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

cd01330
Location:474 → 531

KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...

pfam03137
Location:42 → 636

OATP; Organic Anion Transporter Polypeptide (OATP) family
XM_006229723.5 → XP_006229785.1 solute carrier organic anion transporter family member 2B1 isoform X3

See identical proteins and their annotated locations for XP_006229785.1

UniProtKB/TrEMBL

A0A0G2K880, A0A8L2QE88, A6I6J7

Related

ENSRNOP00000074504.3, ENSRNOT00000091807.3

Conserved Domains (3) summary

cd06174
Location:48 → 291

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

cd01330
Location:474 → 531

KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...

pfam03137
Location:42 → 636

OATP; Organic Anion Transporter Polypeptide (OATP) family
XM_039082439.1 → XP_038938367.1 solute carrier organic anion transporter family member 2B1 isoform X5

UniProtKB/TrEMBL

A0A0G2K880

Conserved Domains (1) summary

cl28910
Location:40 → 526

MFS; Major Facilitator Superfamily