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    Dmrtc2 DMRT-like family C2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499100, updated on 9-Dec-2024

    Summary

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    Symbol
    Dmrtc2provided by RGD
    Full Name
    DMRT-like family C2provided by RGD
    Primary source
    RGD:1583739
    See related
    EnsemblRapid:ENSRNOG00000020109 AllianceGenome:RGD:1583739
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within heterochromatin organization; male meiosis I; and spermatid nucleus elongation. Predicted to be located in XY body. Predicted to be active in nucleus. Orthologous to human DMRTC2 (DMRT like family C2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 31.9), Lung (RPKM 14.6) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dmrtc2 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (89594120..89601761)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (80466259..80473883)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (81734256..81741419)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349556 Neighboring gene CEA cell adhesion molecule 6 Neighboring gene Ly6/Plaur domain containing 4 Neighboring gene ribosomal protein S19 Neighboring gene CD79a molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A mammal-specific Doublesex homolog associates with male sex chromatin and is required for male meiosis. Kim S, et al. PLoS Genet, 2007 Apr 20. PMID 17447844, Free PMC Article
    2. Mice deficient in Dmrt7 show infertility with spermatogenic arrest at pachytene stage. Kawamata M, et al. FEBS Lett, 2006 Nov 27. PMID 17098235
    3. Vertebrate DM domain proteins bind similar DNA sequences and can heterodimerize on DNA. Murphy MW, et al. BMC Mol Biol, 2007 Jul 2. PMID 17605809, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within heterochromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within male meiosis I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within spermatid nucleus elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in XY body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    doublesex- and mab-3-related transcription factor C2
    Names
    doublesex and mab-3 related transcription factor like family C2
    doublesex- and mab-3-related transcription factor C2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109140.1 → NP_001102610.1  doublesex- and mab-3-related transcription factor C2

      See identical proteins and their annotated locations for NP_001102610.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473979
      UniProtKB/TrEMBL
      A6J915, D3ZH91
      Related
      ENSRNOP00000027242.2, ENSRNOT00000027242.7
      Conserved Domains (2) summary
      pfam15791
      Location:242 → 369
      DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
      pfam00751
      Location:38 → 84
      DM; DM DNA binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      89594120..89601761
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270853.1 → XP_063126923.1  doublesex- and mab-3-related transcription factor C2 isoform X4

    2. XM_039087146.2 → XP_038943074.1  doublesex- and mab-3-related transcription factor C2 isoform X3

      UniProtKB/TrEMBL
      A6J915, D3ZH91
      Conserved Domains (2) summary
      pfam15791
      Location:242 → 369
      DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
      pfam00751
      Location:38 → 84
      DM; DM DNA binding domain

    3. XM_008766899.4 → XP_008765121.1  doublesex- and mab-3-related transcription factor C2 isoform X1

      UniProtKB/TrEMBL
      M0RDV0
      Conserved Domains (2) summary
      pfam00751
      Location:65 → 111
      DM; DM DNA binding domain
      pfam15791
      Location:270 → 395
      DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2

    4. XM_008766900.4 → XP_008765122.1  doublesex- and mab-3-related transcription factor C2 isoform X2

      Conserved Domains (2) summary
      pfam00751
      Location:65 → 111
      DM; DM DNA binding domain
      pfam15791
      Location:270 → 361
      DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2

    RNA

    1. XR_010056132.1 RNA Sequence

    2. XR_594301.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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