U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    WWOX WW domain containing oxidoreductase [ Bos taurus (domestic cattle) ]

    Gene ID: 618792, updated on 28-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    WWOXprovided by VGNC
    Official Full Name
    WW domain containing oxidoreductaseprovided by VGNC
    Primary source
    VGNC:VGNC:36977
    See related
    Ensembl:ENSBTAG00000015894
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See WWOX in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (5240500..6171219)

    Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA15 Neighboring gene vesicle amine transport 1 like Neighboring gene C-type lectin domain family 3 member A Neighboring gene keratin-associated protein 5-1-like Neighboring gene microRNA mir-2285al Neighboring gene uncharacterized LOC132342708 Neighboring gene uncharacterized LOC112442190 Neighboring gene uncharacterized LOC132342777 Neighboring gene transfer RNA glycine (anticodon GCC) Neighboring gene MAF bZIP transcription factor

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Comparative mapping and genomic annotation of the bovine oncosuppressor gene WWOX. Manera S, et al. Cytogenet Genome Res, 2009. PMID 20016169
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hippo signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    WW domain-containing oxidoreductase
    NP_001071560.1
    XP_005218456.1
    XP_059732971.1
    XP_059732972.1
    XP_059732973.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001078092.1 → NP_001071560.1  WW domain-containing oxidoreductase

      See identical proteins and their annotated locations for NP_001071560.1

      Status: PROVISIONAL

      Source sequence(s)
      BC119823
      UniProtKB/TrEMBL
      E1U8D1, Q0P5N4
      Related
      ENSBTAP00000080560.1, ENSBTAT00000131292.1
      Conserved Domains (2) summary
      cd09809
      Location:124 → 406
      human_WWOX_like_SDR_c-like; human WWOX (WW domain-containing oxidoreductase)-like, classical (c)-like SDRs
      cd00201
      Location:19 → 47
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      5240500..6171219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059876988.1 → XP_059732971.1  WW domain-containing oxidoreductase isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M6N2

    2. XM_059876989.1 → XP_059732972.1  WW domain-containing oxidoreductase isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LVN4
      Related
      ENSBTAP00000061236.2, ENSBTAT00000086215.2

    3. XM_005218399.5 → XP_005218456.1  WW domain-containing oxidoreductase isoform X3

      UniProtKB/TrEMBL
      A0AAA9S3R7
      Related
      ENSBTAP00000032547.4, ENSBTAT00000032617.5
      Conserved Domains (3) summary
      cd00201
      Location:19 → 47
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00106
      Location:125 → 326
      adh_short; short chain dehydrogenase
      cl21454
      Location:124 → 352
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    4. XM_059876990.1 → XP_059732973.1  WW domain-containing oxidoreductase isoform X4

    RNA

    1. XR_009491178.1 RNA Sequence

      Related
      ENSBTAT00000124928.1

    2. XR_003030202.2 RNA Sequence

    3. XR_009491177.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials