CXCR4 C-X-C motif chemokine receptor 4 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: CXCR4provided by VGNC
Official Full Name: C-X-C motif chemokine receptor 4provided by VGNC
Primary source: VGNC:VGNC:27856
See related: BGD:BT27276
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	2	NC_037329.1 (61250149..61253862)

Chromosome 2 - NC_037329.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cellular detection of the chemokine receptor CXCR4 in bovine mammary glands and its distribution and regulation on bovine leukocytes.
Title: Cellular detection of the chemokine receptor CXCR4 in bovine mammary glands and its distribution and regulation on bovine leukocytes.
Study identified stromal cell-derived factor 1 (SDF1), which was expressed in bovine cumulus-oocyte complexes (COCs), and its receptor CXCR4 in sperm, as a sperm chemoattractants and proposed that SDF1 is a chemotactic factor for bovine sperm to regulate their migration towards an oocyte via the CXCR4 receptor.
Title: Stromal cell-derived factor 1 regulates in vitro sperm migration towards the cumulus-oocyte complex in cattle.
The current analysis failed in identifying a causal mutation on the CXCR4 gene underlying a previously reported quantitative trait loci for cattle trypanotolerance on bovine chromosome 2.
Title: Lack of specific alleles for the bovine chemokine (C-X-C) receptor type 4 (CXCR4) gene in West African cattle questions its role as a candidate for trypanotolerance.
There is a potential link between follicular SDF1/CXCR4 activation and the regulation of ovulation-related genes in cows and horses.
Title: Expression and regulation of stromal cell-derived factor-1 (SDF1) and chemokine CXC motif receptor 4 (CXCR4) in equine and bovine preovulatory follicles.
The combination of low expression of CXCR4 and high expression of IL-10 might be closely concerned with some bias for the production of PI calves.
Title: C-X-C chemokine receptor type 4 and cytokine expressions in cows of a dairy herd with high prevalence of calves persistently infected with bovine viral diarrhea virus.

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General gene information

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Markers

PMC109444P3 (e-PCR)
- UniSTS:270168

PMC109895P1 (e-PCR)
- UniSTS:270179

CXCR4_564 (e-PCR)
- UniSTS:277147

CXCR4 (e-PCR)
- UniSTS:519071

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables C-C chemokine binding	IEA Inferred from Electronic Annotation more info	PubMed
enables C-C chemokine receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in brain development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neurogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: C-X-C chemokine receptor type 4

Names: CXC-R4; CXCR-4; LCR1; LESTR; SDF-1 receptor; chemokine (C-X-C motif) receptor 4; fusin; leukocyte-derived seven transmembrane domain receptor; stromal cell-derived factor 1 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174301.3 → NP_776726.1 C-X-C chemokine receptor type 4

See identical proteins and their annotated locations for NP_776726.1

Status: PROVISIONAL

Source sequence(s)

BC105217

UniProtKB/Swiss-Prot

P25930, Q3MHJ3

UniProtKB/TrEMBL

A0AAF6YI70

Conserved Domains (2) summary

cd15179
Location:40 → 314

7tmA_CXCR4; CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors

pfam12109
Location:6 → 39

CXCR4_N; CXCR4 Chemokine receptor N terminal