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    PTCH1 patched 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 520994, updated on 1-Jan-2025

    Summary

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    Official Symbol
    PTCH1provided by VGNC
    Official Full Name
    patched 1provided by VGNC
    Primary source
    VGNC:VGNC:106881
    See related
    BGD:BT12714; Ensembl:ENSBTAG00000009903
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PTCH1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (82098128..82168564, complement)

    Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene aminopeptidase O (putative) Neighboring gene U6 spliceosomal RNA Neighboring gene microRNA mir-24-1 Neighboring gene FA complementation group C Neighboring gene uncharacterized LOC132345987 Neighboring gene uncharacterized LOC107132716 Neighboring gene uncharacterized LOC101902831

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Bovine anterior pituitary progenitor cell line expresses interleukin (IL)-18 and IL-18 receptor. Nagai Y, et al. J Neuroendocrinol, 2008 Nov. PMID 18761716
    2. Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs. Lopez-Rios J, et al. Nature, 2014 Jul 3. PMID 24990743
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables hedgehog family protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables hedgehog receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables smoothened binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein patched homolog 1
    Names
    patched homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205879.2 → NP_001192808.1  protein patched homolog 1

      See identical proteins and their annotated locations for NP_001192808.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000008
      UniProtKB/TrEMBL
      A0AAA9S7E1, A0AAA9T187
      Related
      ENSBTAP00000079227.1, ENSBTAT00000108249.1
      Conserved Domains (2) summary
      TIGR00918
      Location:42 → 1205
      2A060602; The Eukaryotic (Putative) Sterol Transporter (EST) Family
      pfam12349
      Location:461 → 615
      Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      82098128..82168564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024995742.2 → XP_024851510.1  protein patched homolog 1 isoform X2

      UniProtKB/TrEMBL
      A0AAA9T187, G3N1D5
      Related
      ENSBTAP00000055675.3, ENSBTAT00000064817.3
      Conserved Domains (2) summary
      TIGR00918
      Location:2 → 1140
      2A060602; The Eukaryotic (Putative) Sterol Transporter (EST) Family
      cl27975
      Location:1181 → 1305
      EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)

    2. XM_005210406.5 → XP_005210463.1  protein patched homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0AAA9T187, F1MVV4
      Related
      ENSBTAP00000013074.5, ENSBTAT00000013074.6
      Conserved Domains (2) summary
      TIGR00918
      Location:42 → 1153
      2A060602; The Eukaryotic (Putative) Sterol Transporter (EST) Family
      cl21543
      Location:449 → 563
      MMPL; MMPL family

    3. XM_005210407.5 → XP_005210464.1  protein patched homolog 1 isoform X3

      See identical proteins and their annotated locations for XP_005210464.1

      UniProtKB/TrEMBL
      A0AAA9T187
      Conserved Domains (2) summary
      TIGR00918
      Location:1 → 1055
      2A060602; The Eukaryotic (Putative) Sterol Transporter (EST) Family
      pfam12349
      Location:311 → 465
      Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation

    4. XM_010808162.4 → XP_010806464.1  protein patched homolog 1 isoform X3

      See identical proteins and their annotated locations for XP_010806464.1

      UniProtKB/TrEMBL
      A0AAA9T187
      Conserved Domains (2) summary
      TIGR00918
      Location:1 → 1055
      2A060602; The Eukaryotic (Putative) Sterol Transporter (EST) Family
      pfam12349
      Location:311 → 465
      Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation
    Nucleotide Protein Strain
    Heading Accession and Version

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