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    MYLIP myosin regulatory light chain interacting protein [ Bos taurus (domestic cattle) ]

    Gene ID: 541070, updated on 27-Dec-2024

    Summary

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    Official Symbol
    MYLIPprovided by VGNC
    Official Full Name
    myosin regulatory light chain interacting proteinprovided by VGNC
    Primary source
    VGNC:VGNC:31805
    See related
    Ensembl:ENSBTAG00000004115
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See MYLIP in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (40992081..41012852, complement)

    Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene ataxin 1 Neighboring gene nucleoside-diphosphate kinase NBR-A Neighboring gene uncharacterized LOC132343646 Neighboring gene guanosine monophosphate reductase Neighboring gene uncharacterized LOC132343647 Neighboring gene dystrobrevin binding protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC159760

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MYLIP
    NP_001095723.1
    XP_005223840.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102253.1 → NP_001095723.1  E3 ubiquitin-protein ligase MYLIP

      See identical proteins and their annotated locations for NP_001095723.1

      Status: PROVISIONAL

      Source sequence(s)
      BC149770
      UniProtKB/TrEMBL
      A6QQD1, F1MC62
      Conserved Domains (4) summary
      smart00295
      Location:5 → 125
      B41; Band 4.1 homologues
      cd13195
      Location:120 → 230
      FERM_C_MYLIP_IDOL; FERM domain C-lobe of E3 ubiquitin ligase myosin regulatory light chain-interacting protein (MYLIP; also called inducible degrader of the LDL receptor, IDOL)
      pfam00373
      Location:20 → 125
      FERM_M; FERM central domain
      pfam13920
      Location:318 → 363
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      40992081..41012852 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005223783.4 → XP_005223840.1  E3 ubiquitin-protein ligase MYLIP isoform X1

      UniProtKB/TrEMBL
      A0AAF6DLM3
      Related
      ENSBTAP00000005377.5, ENSBTAT00000005377.6
      Conserved Domains (3) summary
      smart00295
      Location:5 → 190
      B41; Band 4.1 homologues
      cd13195
      Location:185 → 295
      FERM_C_MYLIP_IDOL; FERM domain C-lobe of E3 ubiquitin ligase myosin regulatory light chain-interacting protein (MYLIP; also called inducible degrader of the LDL receptor, IDOL)
      cd16523
      Location:386 → 423
      RING-HC_MYLIP; RING finger, HC subclass, found in myosin regulatory light chain interacting protein (MYLIP) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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