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    TAP2 transporter 2, ATP binding cassette subfamily B member [ Bos taurus (domestic cattle) ]

    Gene ID: 281586, updated on 30-Jan-2025

    Summary

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    Gene symbol
    TAP2
    Gene description
    transporter 2, ATP binding cassette subfamily B member
    See related
    BGD:BT10502; EnsemblRapid:ENSBTAG00070009541
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    ABCB3
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See TAP2 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (7138820..7146579, complement)

    Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene major histocompatibility complex, class II, DO beta Neighboring gene tRNA wybutosine-synthesizing protein 5-like Neighboring gene transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)-like Neighboring gene uncharacterized LOC132343596

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning, sequencing, and characterization of bovine transporter associated with antigen processing 2 ( BoTAP2). Ambagala AP, et al. Immunogenetics, 2002 Apr. PMID 11976789
    2. Physical assignment of the bovine MHC class IIa and class IIb genes. Hess M, et al. Cytogenet Cell Genet, 1999. PMID 10449907
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ABC-type peptide transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables MHC protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptide transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TAP complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    antigen peptide transporter 2
    Names
    ABC-transporter
    ATP-binding cassette, sub-family B (MDR/TAP), member 3
    transporter 2, ABC(ATP binding cassette)
    NP_776647.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174222.2 → NP_776647.1  antigen peptide transporter 2

      See identical proteins and their annotated locations for NP_776647.1

      Status: PROVISIONAL

      Source sequence(s)
      AF318024
      UniProtKB/TrEMBL
      F1MCG5, F1MCG6, Q8SQ31
      Related
      ENSBTAP00070012537.1, ENSBTAT00070021416.1
      Conserved Domains (3) summary
      COG1132
      Location:134 → 697
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
      pfam00664
      Location:160 → 415
      ABC_membrane; ABC transporter transmembrane region
      cl21455
      Location:456 → 679
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      7138820..7146579 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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