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    SPHK2 sphingosine kinase 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 533103, updated on 30-Jan-2025

    Summary

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    Official Symbol
    SPHK2provided by VGNC
    Official Full Name
    sphingosine kinase 2provided by VGNC
    Primary source
    VGNC:VGNC:35211
    See related
    BGD:BT15120; EnsemblRapid:ENSBTAG00070036605
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See SPHK2 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (55264197..55272144)

    Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 83 member E Neighboring gene sperm acrosome associated 4 Neighboring gene ribosomal protein L18 Neighboring gene D-box binding PAR bZIP transcription factor Neighboring gene carbonic anhydrase 11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables D-erythro-sphingosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sphinganine-1-phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sphingosine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sphingosine kinase 2
    XP_015313731.2
    XP_024834995.1
    XP_024834997.1
    XP_024834998.1
    XP_024834999.1
    XP_024835000.1
    XP_024835001.1
    XP_024835002.1
    XP_024835003.1
    XP_024835004.1
    XP_024835006.1
    XP_024835007.1
    XP_059733572.1
    XP_059733573.1
    XP_059733574.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      55264197..55272144
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024979229.2 → XP_024834997.1  sphingosine kinase 2 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MBG6, E1BJM1
      Related
      ENSBTAP00070049723.1, ENSBTAT00070082072.1
      Conserved Domains (2) summary
      cl26464
      Location:378 → 528
      Atrophin-1; Atrophin-1 family
      cl27661
      Location:186 → 380
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]

    2. XM_024979238.2 → XP_024835006.1  sphingosine kinase 2 isoform X6

      Conserved Domains (2) summary
      cl26464
      Location:173 → 323
      Atrophin-1; Atrophin-1 family
      cl27661
      Location:1 → 175
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]

    3. XM_015458245.3 → XP_015313731.2  sphingosine kinase 2 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MBG6, E1BJM1
      Conserved Domains (2) summary
      cl26464
      Location:378 → 528
      Atrophin-1; Atrophin-1 family
      cl27661
      Location:186 → 380
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]

    4. XM_024979230.2 → XP_024834998.1  sphingosine kinase 2 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MBG6, E1BJM1
      Conserved Domains (2) summary
      cl26464
      Location:378 → 528
      Atrophin-1; Atrophin-1 family
      cl27661
      Location:186 → 380
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]

    5. XM_024979231.2 → XP_024834999.1  sphingosine kinase 2 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MBG6, E1BJM1
      Conserved Domains (2) summary
      cl26464
      Location:378 → 528
      Atrophin-1; Atrophin-1 family
      cl27661
      Location:186 → 380
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]

    6. XM_024979232.2 → XP_024835000.1  sphingosine kinase 2 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MBG6, E1BJM1
      Conserved Domains (2) summary
      cl26464
      Location:378 → 528
      Atrophin-1; Atrophin-1 family
      cl27661
      Location:186 → 380
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]

    7. XM_059877590.1 → XP_059733573.1  sphingosine kinase 2 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MBG6, E1BJM1

    8. XM_024979235.2 → XP_024835003.1  sphingosine kinase 2 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1MBG6
      Conserved Domains (2) summary
      cl26464
      Location:342 → 492
      Atrophin-1; Atrophin-1 family
      cl27661
      Location:150 → 344
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]

    9. XM_059877591.1 → XP_059733574.1  sphingosine kinase 2 isoform X5

    10. XM_024979239.2 → XP_024835007.1  sphingosine kinase 2 isoform X6

      Conserved Domains (2) summary
      cl26464
      Location:173 → 323
      Atrophin-1; Atrophin-1 family
      cl27661
      Location:1 → 175
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]

    11. XM_024979227.2 → XP_024834995.1  sphingosine kinase 2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MBG6, A0A3Q1MLS8
      Related
      ENSBTAP00070049715.1, ENSBTAT00070082060.1
      Conserved Domains (2) summary
      cl26464
      Location:386 → 536
      Atrophin-1; Atrophin-1 family
      cl27661
      Location:194 → 388
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]

    12. XM_024979233.2 → XP_024835001.1  sphingosine kinase 2 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1MBG6, A0A3Q1NKI0
      Related
      ENSBTAP00070049710.1, ENSBTAT00070082052.1
      Conserved Domains (2) summary
      cl26464
      Location:369 → 519
      Atrophin-1; Atrophin-1 family
      cl27661
      Location:177 → 371
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]

    13. XM_059877589.1 → XP_059733572.1  sphingosine kinase 2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MBG6, A0A3Q1MLS8

    14. XM_024979236.2 → XP_024835004.1  sphingosine kinase 2 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1MBG6
      Conserved Domains (2) summary
      cl26464
      Location:342 → 492
      Atrophin-1; Atrophin-1 family
      cl27661
      Location:150 → 344
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]

    15. XM_024979234.2 → XP_024835002.1  sphingosine kinase 2 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1MBG6
      Conserved Domains (2) summary
      cl26464
      Location:342 → 492
      Atrophin-1; Atrophin-1 family
      cl27661
      Location:150 → 344
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    Nucleotide Protein Strain
    Heading Accession and Version

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