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    PDE1A phosphodiesterase 1A [ Bos taurus (domestic cattle) ]

    Gene ID: 281969, updated on 1-Jan-2025

    Summary

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    Official Symbol
    PDE1Aprovided by VGNC
    Official Full Name
    phosphodiesterase 1Aprovided by VGNC
    Primary source
    VGNC:VGNC:32671
    See related
    BGD:BT12562; Ensembl:ENSBTAG00000012100
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    PDE1
    Orthologs
    human mouse all
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    Genomic context

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    See PDE1A in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (14053224..14453673)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein E-like Neighboring gene DnaJ heat shock protein family (Hsp40) member C10 Neighboring gene uncharacterized LOC132343572 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 1C Neighboring gene proteolipid protein 2-like Neighboring gene ITPR interacting domain containing 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1) splice variants from bovine cardiac muscle. Das SB, et al. Gene, 2007 Jul 15. PMID 17467927
    2. Implication of calmodulin-dependent phosphodiesterase type 1 during bovine sperm capacitation. Fournier V, et al. J Androl, 2003 Jan-Feb. PMID 12514091
    3. Identification of inhibitory and calmodulin-binding domains of the PDE1A1 and PDE1A2 calmodulin-stimulated cyclic nucleotide phosphodiesterases. Sonnenburg WK, et al. J Biol Chem, 1995 Dec 29. PMID 8537356
    4. Molecular cloning of a cDNA encoding the "61-kDa" calmodulin-stimulated cyclic nucleotide phosphodiesterase. Tissue-specific expression of structurally related isoforms. Sonnenburg WK, et al. J Biol Chem, 1993 Jan 5. PMID 7678006
    5. Evidence for domain organization within the 61-kDa calmodulin-dependent cyclic nucleotide phosphodiesterase from bovine brain. Charbonneau H, et al. Biochemistry, 1991 Aug 13. PMID 1651111

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The original finding was the identification and purification of a vinpocetine and muscarinic antagonist-inhibited and CaM-activated plasma membrane-bound PDE1A, linked to M(2)AChR.
      Title: A novel PDE1A coupled to M2AChR at plasma membranes from bovine tracheal smooth muscle.
    2. analysis of calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1) splice variants from bovine cardiac muscle
      Title: Calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1) splice variants from bovine cardiac muscle.
    3. Although cAMP regulation by PDE 1 may occur early during capacitation, downstream events appear to prevent full capacitation from occurring prematurely.
      Title: Implication of calmodulin-dependent phosphodiesterase type 1 during bovine sperm capacitation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
    Names
    61 kDa Cam-PDE
    calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
    calmodulin-dependent phosphodiesterase type 1
    cam-PDE 1A
    nucleotide phosphodiesterase, 3'-5'-cyclic
    phosphodiesterase 1A, calmodulin-dependent
    NP_776839.1
    XP_005202314.3
    XP_010800144.2
    XP_010800145.2
    XP_010800146.1
    XP_010800148.1
    XP_015330124.1
    XP_024854622.1
    XP_059747708.1
    XP_059747713.1
    XP_059747716.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174414.3 → NP_776839.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

      See identical proteins and their annotated locations for NP_776839.1

      Status: PROVISIONAL

      Source sequence(s)
      BC123449
      UniProtKB/TrEMBL
      A0AAF6YX17
      Related
      ENSBTAP00000016060.6, ENSBTAT00000016060.7
      Conserved Domains (2) summary
      pfam00233
      Location:202 → 418
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:61 → 117
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      14053224..14453673
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059891725.1 → XP_059747708.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X3

      UniProtKB/TrEMBL
      A0AAA9TY04

    2. XM_015474638.3 → XP_015330124.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X3

      UniProtKB/TrEMBL
      A0AAA9TY04
      Conserved Domains (2) summary
      pfam00233
      Location:218 → 434
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:77 → 133
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    3. XM_010801844.4 → XP_010800146.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X3

      See identical proteins and their annotated locations for XP_010800146.1

      UniProtKB/TrEMBL
      A0AAA9TY04
      Conserved Domains (2) summary
      pfam00233
      Location:218 → 434
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:77 → 133
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    4. XM_059891730.1 → XP_059747713.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X6

    5. XM_010801842.4 → XP_010800144.2  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1

      UniProtKB/TrEMBL
      A0AAA9TY04
      Conserved Domains (2) summary
      pfam00233
      Location:249 → 465
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:108 → 164
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    6. XM_005202257.5 → XP_005202314.3  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X2

      UniProtKB/TrEMBL
      A0AAA9TY04
      Related
      ENSBTAP00000102081.1, ENSBTAT00000107295.1
      Conserved Domains (2) summary
      pfam00233
      Location:249 → 465
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:108 → 164
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    7. XM_010801843.4 → XP_010800145.2  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X2

      UniProtKB/TrEMBL
      A0AAA9TY04
      Conserved Domains (2) summary
      pfam00233
      Location:249 → 465
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:108 → 164
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    8. XM_024998854.2 → XP_024854622.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X5

      UniProtKB/TrEMBL
      A0AAF6YX17
      Conserved Domains (2) summary
      pfam00233
      Location:202 → 418
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:61 → 117
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    9. XM_010801846.4 → XP_010800148.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X4

      UniProtKB/TrEMBL
      A0AAA9TUX0, A0AAF6YX17
      Related
      ENSBTAP00000102420.1, ENSBTAT00000093539.1
      Conserved Domains (2) summary
      pfam00233
      Location:202 → 418
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:61 → 117
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    10. XM_059891733.1 → XP_059747716.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X7

      UniProtKB/TrEMBL
      A0AAF6ZKA2
      Related
      ENSBTAP00000051204.2, ENSBTAT00000052318.3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14100.3 GenPept UniProtKB/Swiss-Prot:P14100

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