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    ADAM10 ADAM metallopeptidase domain 10 [ Bos taurus (domestic cattle) ]

    Gene ID: 282132, updated on 30-Jan-2025

    Summary

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    Official Symbol
    ADAM10provided by VGNC
    Official Full Name
    ADAM metallopeptidase domain 10provided by VGNC
    Primary source
    VGNC:VGNC:25604
    See related
    BGD:BT15627; EnsemblRapid:ENSBTAG00070032389
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    ADAM 10
    Orthologs
    human mouse all
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    Genomic context

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    See ADAM10 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (51535794..51679930)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene MINDY lysine 48 deubiquitinase 2 Neighboring gene iron-sulfur cluster scaffold homolog (E. coli)-like Neighboring gene uncharacterized LOC101903685 Neighboring gene uncharacterized LOC112448468 Neighboring gene lipase C, hepatic type Neighboring gene uncharacterized LOC112448583 Neighboring gene methylosome subunit pICln-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A basolateral sorting signal directs ADAM10 to adherens junctions and is required for its function in cell migration. Wild-Bode C, et al. J Biol Chem, 2006 Aug 18. PMID 16777847
    2. Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Lammich S, et al. Proc Natl Acad Sci U S A, 1999 Mar 30. PMID 10097139, Free PMC Article
    3. A disintegrin and metalloprotease 10 activity sheds the ectodomain of the amyloid precursor-like protein 2 and regulates protein expression in proximal tubule cells. Cong R, et al. Am J Physiol Cell Physiol, 2011 Jun. PMID 21325636, Free PMC Article
    4. Functional role of N-glycosylation from ADAM10 in processing, localization and activity of the enzyme. Escrevente C, et al. Biochim Biophys Acta, 2008 Jun. PMID 18381078
    5. Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types. Howard L, et al. Biochem J, 1996 Jul 1. PMID 8694785, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that ADAM10 and APLP2 are expressed in proximal tubule cells, and that ADAM10 activity has a pronounced effect on expression of specific brush-border proteins.
      Title: A disintegrin and metalloprotease 10 activity sheds the ectodomain of the amyloid precursor-like protein 2 and regulates protein expression in proximal tubule cells.
    2. N-glycosylation is crucial for ADAM10 processing and resistance to proteolysis, and results suggest that it is required for full-enzyme activity.
      Title: Functional role of N-glycosylation from ADAM10 in processing, localization and activity of the enzyme.
    3. Intracellular trafficking of ADAM10 critically requires a novel sorting signal within its cytoplasmic domain.
      Title: A basolateral sorting signal directs ADAM10 to adherens junctions and is required for its function in cell migration.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in membrane protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 10
    Names
    kuzbanian protein homolog
    mammalian disintegrin-metalloprotease
    myelin-associated metalloproteinase
    NP_776921.1
    XP_024853043.1
    XP_024853044.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174496.3 → NP_776921.1  disintegrin and metalloproteinase domain-containing protein 10 preproprotein

      See identical proteins and their annotated locations for NP_776921.1

      Status: VALIDATED

      Source sequence(s)
      NKLS02000010
      UniProtKB/Swiss-Prot
      A8E663, Q10741
      UniProtKB/TrEMBL
      A0AAA9TVF8
      Related
      ENSBTAP00070044748.1, ENSBTAT00070073432.1
      Conserved Domains (4) summary
      smart00050
      Location:466 → 545
      DISIN; Homologues of snake disintegrins
      cd04270
      Location:220 → 459
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
      pfam01562
      Location:46 → 146
      Pep_M12B_propep; Reprolysin family propeptide
      pfam13574
      Location:240 → 444
      Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      51535794..51679930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024997276.2 → XP_024853044.1  disintegrin and metalloproteinase domain-containing protein 10 isoform X1

      UniProtKB/TrEMBL
      A0AAA9TVF8
      Conserved Domains (3) summary
      smart00050
      Location:392 → 471
      DISIN; Homologues of snake disintegrins
      cd04270
      Location:146 → 385
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
      pfam01562
      Location:2 → 67
      Pep_M12B_propep; Reprolysin family propeptide

    2. XM_024997275.2 → XP_024853043.1  disintegrin and metalloproteinase domain-containing protein 10 isoform X1

      UniProtKB/TrEMBL
      A0AAA9TVF8
      Related
      ENSBTAP00070044675.1, ENSBTAT00070073329.1
      Conserved Domains (3) summary
      smart00050
      Location:392 → 471
      DISIN; Homologues of snake disintegrins
      cd04270
      Location:146 → 385
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
      pfam01562
      Location:2 → 67
      Pep_M12B_propep; Reprolysin family propeptide
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q10741.1 GenPept UniProtKB/Swiss-Prot:Q10741

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.