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    CTSV cathepsin V [ Bos taurus (domestic cattle) ]

    Gene ID: 281108, updated on 1-Jan-2025

    Summary

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    Gene symbol
    CTSV
    Gene description
    cathepsin V
    See related
    BGD:BT12282; Ensembl:ENSBTAG00000017077
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CTSL; CTSL1; CTSL2
    Annotation information
    Annotation category: partial on reference assembly
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    Genomic context

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    See CTSV in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (83553396..83558602, complement)

    Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S15a pseudogene Neighboring gene zinc finger protein 782 Neighboring gene uncharacterized LOC112447907 Neighboring gene protein FAM240B-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Cathepsin L expression is directed to secretory vesicles for enkephalin neuropeptide biosynthesis and secretion. Hwang SR, et al. J Biol Chem, 2007 Mar 30. PMID 17244622
    2. Bovine cathepsins S and L: isolation and amino acid sequences. Dolenc I, et al. Biol Chem Hoppe Seyler, 1992 Jul. PMID 1515067
    3. The complete amino acid sequence of bovine cathepsin S and a partial sequence of bovine cathepsin L. Ritonja A, et al. FEBS Lett, 1991 Jun 3. PMID 2044774
    4. Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. Yasothornsrikul S, et al. Proc Natl Acad Sci U S A, 2003 Aug 5. PMID 12869695, Free PMC Article
    5. Cathepsins S, B and L with aminopeptidases display β-secretase activity associated with the pathogenesis of Alzheimer's disease. Schechter I, et al. Biol Chem, 2011 Apr. PMID 21585286

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The cathepsin L deserves further evaluation as therapeutic targets to develop disease modifying drugs to treat Alzheimer's disease.
      Title: Cathepsins S, B and L with aminopeptidases display β-secretase activity associated with the pathogenesis of Alzheimer's disease.
    2. Cathepsin L has an previously uncharacterized biological role in the production of [Met]enkephalin, an endogenous peptide neurotransmitter
      Title: Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter.
    3. Secretory vesicle function of cathepsin L for biosynthesis of active enkephalin opioid peptide contrasts with its function in lysosomes for protein degradation.
      Title: Cathepsin L expression is directed to secretory vesicles for enkephalin neuropeptide biosynthesis and secretion.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activator activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis involved in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cathepsin L2
    Names
    cathepsin L
    cathepsin L1
    cathepsin L2 preproprotein
    NP_776457.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174032.2 → NP_776457.1  cathepsin L2 precursor

      See identical proteins and their annotated locations for NP_776457.1

      Status: PROVISIONAL

      Source sequence(s)
      X91755
      UniProtKB/Swiss-Prot
      Q5E998
      Related
      ENSBTAP00000022710.3, ENSBTAT00000022710.5
      Conserved Domains (2) summary
      smart00848
      Location:29 → 87
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:114 → 333
      Peptidase_C1; Papain family cysteine protease

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      83553396..83558602 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25975.3 GenPept UniProtKB/Swiss-Prot:P25975
    Q5E998.1 GenPept UniProtKB/Swiss-Prot:Q5E998

    Gene LinkOut

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