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    SLC25A12 solute carrier family 25 member 12 [ Bos taurus (domestic cattle) ]

    Gene ID: 539494, updated on 30-Jan-2025

    Summary

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    Official Symbol
    SLC25A12provided by VGNC
    Official Full Name
    solute carrier family 25 member 12provided by VGNC
    Primary source
    VGNC:VGNC:34743
    See related
    BGD:BT14093; EnsemblRapid:ENSBTAG00070005151
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See SLC25A12 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (24637412..24736034)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene methionyl aminopeptidase type 1D, mitochondrial Neighboring gene histone acetyltransferase 1 Neighboring gene dynein cytoplasmic 1 intermediate chain 2 Neighboring gene small ribosomal subunit protein eS26-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables L-aspartate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables L-glutamate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-glutamate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in aspartate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in malate-aspartate shuttle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial
    Names
    solute carrier family 25 (mitochondrial carrier, Aralar), member 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101194.2 → NP_001094664.1  electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

      See identical proteins and their annotated locations for NP_001094664.1

      Status: PROVISIONAL

      Source sequence(s)
      BC148908
      UniProtKB/TrEMBL
      A0A3Q1MLV2, A6QNM9
      Related
      ENSBTAP00070006662.1, ENSBTAT00070011803.1
      Conserved Domains (5) summary
      COG5126
      Location:147 → 217
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd15900
      Location:89 → 114
      EFh_MICU; EF-hand motif [structural motif]
      cl28896
      Location:89 → 158
      EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins
      pfam00153
      Location:512 → 607
      Mito_carr; Mitochondrial carrier protein
      pfam13499
      Location:12 → 78
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      24637412..24736034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005202346.4 → XP_005202403.1  electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_005202403.1

      UniProtKB/TrEMBL
      A0A3Q1MLV2, A0AAA9SCC8
      Related
      ENSBTAP00070006655.1, ENSBTAT00070011796.1
      Conserved Domains (4) summary
      pfam00153
      Location:530 → 625
      Mito_carr; Mitochondrial carrier protein
      cd15900
      Location:107 → 132
      EFh_MICU; EF-hand motif [structural motif]
      cl25352
      Location:30 → 130
      EFh_PEF; The penta-EF hand (PEF) family
      cl28896
      Location:107 → 176
      EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins

    2. XM_015474952.3 → XP_015330438.1  electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A3Q1M6G7, A0AAA9TFL5
      Related
      ENSBTAP00070006651.1, ENSBTAT00070011792.1
      Conserved Domains (2) summary
      COG5126
      Location:58 → 128
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam00153
      Location:423 → 518
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein Strain
    Heading Accession and Version

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