U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PTPRC protein tyrosine phosphatase receptor type C [ Bos taurus (domestic cattle) ]

    Gene ID: 407152, updated on 30-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    PTPRCprovided by VGNC
    Official Full Name
    protein tyrosine phosphatase receptor type Cprovided by VGNC
    Primary source
    VGNC:VGNC:33546
    See related
    BGD:BT12319; EnsemblRapid:ENSBTAG00070007626
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    cd45
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PTPRC in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (77540603..77670102)

    Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112441875 Neighboring gene uncharacterized LOC104974538 Neighboring gene U6 spliceosomal RNA Neighboring gene glycine cleavage system H protein, mitochondrial-like Neighboring gene uncharacterized LOC104974541 Neighboring gene microRNA mir-181b-1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Allelic Variation in Protein Tyrosine Phosphatase Receptor Type-C in Cattle Influences Erythrocyte, Leukocyte and Humoral Responses to Infestation With the Cattle Tick Rhipicephalus australis. Jonsson NN, et al. Front Immunol, 2021. PMID 34305905, Free PMC Article
    2. The CD45 locus in cattle: allelic polymorphism and evidence for exceptional positive natural selection. Ballingall KT, et al. Immunogenetics, 2001. PMID 11220630
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Allelic Variation in Protein Tyrosine Phosphatase Receptor Type-C in Cattle Influences Erythrocyte, Leukocyte and Humoral Responses to Infestation With the Cattle Tick Rhipicephalus australis.
      Title: Allelic Variation in Protein Tyrosine Phosphatase Receptor Type-C in Cattle Influences Erythrocyte, Leukocyte and Humoral Responses to Infestation With the Cattle Tick Rhipicephalus australis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in synaptic membrane adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    receptor-type tyrosine-protein phosphatase C
    Names
    membrane tyrosine phosphatase
    NP_001193452.1
    XP_005217387.1
    XP_010811847.1
    XP_010811849.1
    XP_015330753.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206523.1 → NP_001193452.1  receptor-type tyrosine-protein phosphatase C precursor

      Status: VALIDATED

      Source sequence(s)
      AAFC03001410, AAFC03104476, BC148881, EH207654
      UniProtKB/TrEMBL
      F1MJS9
      Related
      ENSBTAP00070010155.1, ENSBTAT00070017467.1
      Conserved Domains (6) summary
      smart00194
      Location:491 → 750
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:519 → 750
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:324 → 411
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:233 → 302
      fn3; Fibronectin type III domain
      pfam12453
      Location:7 → 32
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:73 → 126
      CD45; Leukocyte receptor CD45

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      77540603..77670102
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015475267.3 → XP_015330753.1  receptor-type tyrosine-protein phosphatase C isoform X3

      UniProtKB/TrEMBL
      A0AAA9U0X3, F1MJS9
      Conserved Domains (6) summary
      smart00194
      Location:491 → 750
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:519 → 750
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:324 → 411
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:233 → 302
      fn3; Fibronectin type III domain
      pfam12453
      Location:7 → 32
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:73 → 126
      CD45; Leukocyte receptor CD45

    2. XM_005217330.5 → XP_005217387.1  receptor-type tyrosine-protein phosphatase C isoform X1

      UniProtKB/TrEMBL
      A0AAA9S9Q3, F1MJS9
      Related
      ENSBTAP00070010082.1, ENSBTAT00070017360.1
      Conserved Domains (8) summary
      smart00194
      Location:681 → 940
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:709 → 940
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:514 → 601
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:423 → 492
      fn3; Fibronectin type III domain
      pfam12453
      Location:7 → 32
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:263 → 316
      CD45; Leukocyte receptor CD45
      pfam16612
      Location:27 → 141
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16788
      Location:113 → 190
      ATF7IP_BD; ATF-interacting protein binding domain

    3. XM_010813545.4 → XP_010811847.1  receptor-type tyrosine-protein phosphatase C isoform X2

      UniProtKB/TrEMBL
      A0AAA9SPC6, F1MJS9
      Related
      ENSBTAP00070010100.1, ENSBTAT00070017391.1
      Conserved Domains (7) summary
      smart00194
      Location:914 → 1196
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:650 → 881
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:455 → 542
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:364 → 433
      fn3; Fibronectin type III domain
      pfam12453
      Location:7 → 32
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:204 → 257
      CD45; Leukocyte receptor CD45
      cl25495
      Location:54 → 193
      Endomucin; Endomucin

    4. XM_010813547.4 → XP_010811849.1  receptor-type tyrosine-protein phosphatase C isoform X4

      UniProtKB/TrEMBL
      F1MJS9
      Conserved Domains (6) summary
      smart00194
      Location:759 → 1041
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:495 → 726
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:300 → 387
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:209 → 278
      fn3; Fibronectin type III domain
      pfam12453
      Location:7 → 32
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:49 → 102
      CD45; Leukocyte receptor CD45
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.