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    TJP3 tight junction protein 3 [ Bos taurus (domestic cattle) ]

    Gene ID: 407100, updated on 30-Jan-2025

    Summary

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    Official Symbol
    TJP3provided by VGNC
    Official Full Name
    tight junction protein 3provided by VGNC
    Primary source
    VGNC:VGNC:35883
    See related
    BGD:BT25985; EnsemblRapid:ENSBTAG00070003229
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    zo3
    Orthologs
    human mouse all
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    Genomic context

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    See TJP3 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (20221722..20252247, complement)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L54 Neighboring gene amyloid beta precursor protein binding family A member 3 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase type 1 gamma Neighboring gene cactin, spliceosome C complex subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC137498

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell junction organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in establishment of endothelial intestinal barrier IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of blood-brain barrier permeability IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein localization to cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tight junction protein ZO-3
    Names
    tight junction protein 3 (zona occludens 3)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045874.1 → NP_001039339.1  tight junction protein ZO-3

      See identical proteins and their annotated locations for NP_001039339.1

      Status: PROVISIONAL

      Source sequence(s)
      BC114050
      UniProtKB/TrEMBL
      F1MEC0, Q29RS2
      Related
      ENSBTAP00070004372.1, ENSBTAT00070007456.1
      Conserved Domains (4) summary
      smart00072
      Location:584 → 758
      GuKc; Guanylate kinase homologues
      cd00992
      Location:376 → 454
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:613 → 757
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:470 → 540
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      20221722..20252247 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010806965.4 → XP_010805267.1  tight junction protein ZO-3 isoform X2

      See identical proteins and their annotated locations for XP_010805267.1

      UniProtKB/TrEMBL
      F1MEC0
      Conserved Domains (4) summary
      smart00072
      Location:584 → 758
      GuKc; Guanylate kinase homologues
      cd00992
      Location:376 → 454
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:613 → 757
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:470 → 540
      SH3; Src Homology 3 domain superfamily

    2. XM_005208914.5 → XP_005208971.1  tight junction protein ZO-3 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MSB9
      Related
      ENSBTAP00070004362.1, ENSBTAT00070007430.1
      Conserved Domains (4) summary
      smart00072
      Location:593 → 767
      GuKc; Guanylate kinase homologues
      cd00992
      Location:385 → 463
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:622 → 766
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:479 → 549
      SH3; Src Homology 3 domain superfamily

    3. XM_010806966.4 → XP_010805268.1  tight junction protein ZO-3 isoform X2

      See identical proteins and their annotated locations for XP_010805268.1

      UniProtKB/TrEMBL
      F1MEC0
      Conserved Domains (4) summary
      smart00072
      Location:584 → 758
      GuKc; Guanylate kinase homologues
      cd00992
      Location:376 → 454
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:613 → 757
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:470 → 540
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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