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    FGFR2 fibroblast growth factor receptor 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 404193, updated on 30-Jan-2025

    Summary

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    Official Symbol
    FGFR2provided by VGNC
    Official Full Name
    fibroblast growth factor receptor 2provided by VGNC
    Primary source
    VGNC:VGNC:28987
    See related
    BGD:BT11084; EnsemblRapid:ENSBTAG00070024332
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    FGFR
    Orthologs
    human mouse all
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    Genomic context

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    See FGFR2 in Genome Data Viewer
    Location:
    chromosome: 26
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 26 NC_037353.1 (41450677..41557736, complement)

    Chromosome 26 - NC_037353.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 11 Neighboring gene uncharacterized LOC132343967 Neighboring gene uncharacterized LOC132343968 Neighboring gene arginyltransferase 1 Neighboring gene uncharacterized LOC132343969 Neighboring gene NSE4 homolog A, SMC5-SMC6 complex component Neighboring gene ATE1 opposite strand

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037353.1 Chromosome 26 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A de novo missense mutation of FGFR2 causes facial dysplasia syndrome in Holstein cattle. Agerholm JS, et al. BMC Genet, 2017 Aug 2. PMID 28768473, Free PMC Article
    2. Conserved roles of fibroblast growth factor receptor 2 signaling in the regulation of inner cell mass development in bovine blastocysts. Akizawa H, et al. Mol Reprod Dev, 2016 Jun. PMID 27060901
    3. Fibroblast growth factor (FGF)-1, FGF2, FGF7 and FGF receptors are uniformly expressed in trophoblast giant cells during restricted trophoblast invasion in cows. Pfarrer C, et al. Placenta, 2006 Jun-Jul. PMID 16129484
    4. Detection of mRNA and immunoreactive proteins for acidic and basic fibroblast growth factor and expression of the fibroblast growth factor receptors in the bovine oviduct. Gabler C, et al. J Reprod Fertil, 1997 Mar. PMID 9155730
    5. FGF10 inhibits dominant follicle growth and estradiol secretion in vivo in cattle. Gasperin BG, et al. Reproduction, 2012 Jun. PMID 22457435

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FGFR2 signaling appears to be associated with the regulation of inner cell mass development and proliferation during blastocyst formation in cattle.
      Title: Conserved roles of fibroblast growth factor receptor 2 signaling in the regulation of inner cell mass development in bovine blastocysts.
    2. activation of FGFR1 and FGFR2 by uterine- and endometrial-derived FGF2 stimulates PI3K/AKT and mitogen-activated protein kinase pathways for development of the porcine uterus and improvement of litter size
      Title: Stimulatory effects of fibroblast growth factor 2 on proliferation and migration of uterine luminal epithelial cells during early pregnancy.
    3. it is highly likely that the missense mutation in the FGFR2 gene caused the bovine facial dysplasia syndrome phenotype in a dominant mode of inheritance.
      Title: A de novo missense mutation of FGFR2 causes facial dysplasia syndrome in Holstein cattle.
    4. FGF10 and its receptor FGFR2b are more expressed in subordinate follicles; FGF10 acts as an important regulator of follicular growth in cattle.
      Title: FGF10 inhibits dominant follicle growth and estradiol secretion in vivo in cattle.
    5. Alterations in the expression of VEGF-A and bFGF systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
      Title: Somatic cell nuclear transfer is associated with altered expression of angiogenic factor systems in bovine placentomes at term.
    6. These data support a role for FGF10 and fibroblast growth factor receptor 2B in signaling to granulosa cells from theca cells and/or the oocyte.(fibroblast growth factor receptor 2B)
      Title: Expression and function of fibroblast growth factor 10 and its receptor, fibroblast growth factor receptor 2B, in bovine follicles.
    7. FGF10 mRNA expression did not change during functional luteolysis, whereas FGFR2B mRNA abundance decreased significantly at 2, 4, and 12 hr after PGF2alpha, and returned to pretreatment levels for the period 24-64 hr post-PGF2alpha
      Title: Expression of fibroblast growth factor 10 and its receptor, fibroblast growth factor receptor 2B, in the bovine corpus luteum.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables fibroblast growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables fibroblast growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fibroblast growth factor receptor 2
    Names
    fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome)
    NP_001192239.1
    XP_010818391.1
    XP_010818393.1
    XP_010818400.1
    XP_024841253.1
    XP_059737723.1
    XP_059737724.1
    XP_059737725.1
    XP_059737726.1
    XP_059737727.1
    XP_059737728.1
    XP_059737729.1
    XP_059737730.1
    XP_059737731.1
    XP_059737732.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205310.2 → NP_001192239.1  fibroblast growth factor receptor 2 precursor

      See identical proteins and their annotated locations for NP_001192239.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000026
      UniProtKB/TrEMBL
      A7E310
      Related
      ENSBTAP00070032913.1, ENSBTAT00070054930.1
      Conserved Domains (5) summary
      cd05101
      Location:474 → 786
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam18123
      Location:391 → 421
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd00096
      Location:275 → 278
      Ig; Ig strand A [structural motif]
      cd05857
      Location:173 → 267
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:275 → 377
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037353.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      41450677..41557736 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010820098.4 → XP_010818400.1  fibroblast growth factor receptor 2 isoform X13

      See identical proteins and their annotated locations for XP_010818400.1

      UniProtKB/TrEMBL
      J9QCT8
      Related
      ENSBTAP00070032872.1, ENSBTAT00070054876.1
      Conserved Domains (4) summary
      cd05101
      Location:358 → 670
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam18123
      Location:275 → 305
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd05857
      Location:58 → 152
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cd05858
      Location:160 → 264
      IgI_3_FGFR2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); member of the I-set of Ig superfamily (IgSF) domains

    2. XM_059881748.1 → XP_059737731.1  fibroblast growth factor receptor 2 isoform X12

      UniProtKB/TrEMBL
      J9QCT8

    3. XM_059881747.1 → XP_059737730.1  fibroblast growth factor receptor 2 isoform X11

      UniProtKB/TrEMBL
      J9QD94

    4. XM_059881745.1 → XP_059737728.1  fibroblast growth factor receptor 2 isoform X9

      UniProtKB/TrEMBL
      J9QDG0

    5. XM_059881749.1 → XP_059737732.1  fibroblast growth factor receptor 2 isoform X14

      UniProtKB/TrEMBL
      J9QDU0

    6. XM_059881746.1 → XP_059737729.1  fibroblast growth factor receptor 2 isoform X10

      UniProtKB/TrEMBL
      A0A9E8ABF4, J9QD94

    7. XM_059881744.1 → XP_059737727.1  fibroblast growth factor receptor 2 isoform X8

      UniProtKB/TrEMBL
      J9QD94

    8. XM_010820089.4 → XP_010818391.1  fibroblast growth factor receptor 2 isoform X3

      See identical proteins and their annotated locations for XP_010818391.1

      UniProtKB/TrEMBL
      A7E310, F1MNW2
      Related
      ENSBTAP00070032882.1, ENSBTAT00070054888.1
      Conserved Domains (6) summary
      cd05101
      Location:473 → 785
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam18123
      Location:390 → 420
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd00096
      Location:50 → 53
      Ig; Ig strand A [structural motif]
      cd05857
      Location:173 → 267
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cd05858
      Location:275 → 379
      IgI_3_FGFR2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:50 → 143
      Ig; Immunoglobulin domain

    9. XM_010820091.4 → XP_010818393.1  fibroblast growth factor receptor 2 isoform X7

      See identical proteins and their annotated locations for XP_010818393.1

      UniProtKB/TrEMBL
      J9QDM6
      Conserved Domains (6) summary
      cd05101
      Location:473 → 785
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam18123
      Location:390 → 420
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd00096
      Location:50 → 53
      Ig; Ig strand A [structural motif]
      cd05857
      Location:173 → 267
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cd05858
      Location:275 → 379
      IgI_3_FGFR2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:50 → 143
      Ig; Immunoglobulin domain

    10. XM_059881741.1 → XP_059737724.1  fibroblast growth factor receptor 2 isoform X2

      UniProtKB/TrEMBL
      A7E310

    11. XM_024985485.2 → XP_024841253.1  fibroblast growth factor receptor 2 isoform X6

      UniProtKB/TrEMBL
      J9QDM6
      Conserved Domains (5) summary
      cd05101
      Location:474 → 786
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam18123
      Location:391 → 421
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd00096
      Location:275 → 278
      Ig; Ig strand A [structural motif]
      cd05857
      Location:173 → 267
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:275 → 377
      Ig; Immunoglobulin domain

    12. XM_059881740.1 → XP_059737723.1  fibroblast growth factor receptor 2 isoform X1

      UniProtKB/TrEMBL
      A7E310

    13. XM_059881742.1 → XP_059737725.1  fibroblast growth factor receptor 2 isoform X4

      UniProtKB/TrEMBL
      J9QDM6

    14. XM_059881743.1 → XP_059737726.1  fibroblast growth factor receptor 2 isoform X5

      UniProtKB/TrEMBL
      A0A3Q1LRU7
    Nucleotide Protein Strain
    Heading Accession and Version

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