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    KLRD1 killer cell lectin-like receptor subfamily D, member 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 444877, updated on 30-Jan-2025

    Summary

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    Gene symbol
    KLRD1
    Gene description
    killer cell lectin-like receptor subfamily D, member 1
    See related
    BGD:BT27451; EnsemblRapid:ENSBTAG00070027969
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CD94; CD94-1
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    Genomic context

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    See KLRD1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (99623592..99660578, complement)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100847813 Neighboring gene killer cell lectin like receptor K1 Neighboring gene natural killer cells antigen CD94 Neighboring gene uncharacterized LOC132345341

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Complexity in the cattle CD94/NKG2 gene families. Birch J, et al. Immunogenetics, 2007 Apr. PMID 17285285
    2. Natural killer cell receptors in cattle: a bovine killer cell immunoglobulin-like receptor multigene family contains members with divergent signaling motifs. Storset AK, et al. Eur J Immunol, 2003 Apr. PMID 12672064
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables (1->3)-beta-D-glucan binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables pattern recognition receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to molecule of fungal origin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in detection of fungus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in detection of molecule of fungal origin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phagocytosis, recognition IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cytokine production involved in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of killing of cells of another organism IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of lymphocyte activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of natural killer cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of wound healing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in stimulatory C-type lectin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    natural killer cells antigen CD94
    Names
    killer cell lectin-like receptor family D member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002890.1 → NP_001002890.1  natural killer cells antigen CD94

      See identical proteins and their annotated locations for NP_001002890.1

      Status: PROVISIONAL

      Source sequence(s)
      AF422180
      UniProtKB/Swiss-Prot
      A3R3C2, A3R3C3, A3R3C4, Q863H3
      Related
      ENSBTAP00070038271.1, ENSBTAT00070063755.1
      Conserved Domains (1) summary
      cd03593
      Location:72 → 187
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      99623592..99660578 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059886145.1 → XP_059742128.1  natural killer cells antigen CD94 isoform X1

    2. XM_024991426.2 → XP_024847194.1  natural killer cells antigen CD94 isoform X1

      Conserved Domains (1) summary
      cd03593
      Location:95 → 218
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    3. XM_059886146.1 → XP_059742129.1  natural killer cells antigen CD94 isoform X2

      UniProtKB/TrEMBL
      A0A2Z2AR18

    4. XM_015471264.3 → XP_015326750.1  natural killer cells antigen CD94 isoform X2

      UniProtKB/TrEMBL
      A0A2Z2AR18
      Conserved Domains (1) summary
      cd03593
      Location:72 → 177
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    RNA

    1. XR_009494390.1 RNA Sequence

    2. XR_009494389.1 RNA Sequence

    3. XR_009494391.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q863H3.2 GenPept UniProtKB/Swiss-Prot:Q863H3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials