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    AFG3L2 AFG3 like matrix AAA peptidase subunit 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 515757, updated on 1-Jan-2025

    Summary

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    Official Symbol
    AFG3L2provided by VGNC
    Official Full Name
    AFG3 like matrix AAA peptidase subunit 2provided by VGNC
    Primary source
    VGNC:VGNC:25714
    See related
    BGD:BT23957; Ensembl:ENSBTAG00000011250
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See AFG3L2 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 24 NC_037351.1 (42810259..42829334, complement)

    Chromosome 24 - NC_037351.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132343779 Neighboring gene cell death inducing DFFA like effector a Neighboring gene tubulin beta 6 class V Neighboring gene PRELI domain containing 3A Neighboring gene spire type actin nucleation factor 1 Neighboring gene S-methyl-5'-thioadenosine phosphorylase pseudogene

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037351.1 Chromosome 24 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC127067

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP-dependent peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial protein processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of m-AAA complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial inner membrane m-AAA protease component AFG3L2
    Names
    AFG3 ATPase family gene 3-like 2
    AFG3-like protein 2 (Paraplegin-like protein)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001046211.1 → NP_001039676.1  mitochondrial inner membrane m-AAA protease component AFG3L2

      See identical proteins and their annotated locations for NP_001039676.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105322
      UniProtKB/Swiss-Prot
      Q2KJI7
      UniProtKB/TrEMBL
      A0AAA9SD18
      Related
      ENSBTAP00000081417.1, ENSBTAT00000124725.1
      Conserved Domains (4) summary
      TIGR01241
      Location:254 → 747
      FtsH_fam; ATP-dependent metalloprotease FtsH
      pfam00004
      Location:346 → 477
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam01434
      Location:563 → 745
      Peptidase_M41; Peptidase family M41
      pfam06480
      Location:147 → 243
      FtsH_ext; FtsH Extracellular

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037351.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      42810259..42829334 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059880810.1 → XP_059736793.1  mitochondrial inner membrane m-AAA protease component AFG3L2 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SD18, A0AAA9SFE9
      Related
      ENSBTAP00000082336.1, ENSBTAT00000093182.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2KJI7.1 GenPept UniProtKB/Swiss-Prot:Q2KJI7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.