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    TRIM37 tripartite motif containing 37 [ Bos taurus (domestic cattle) ]

    Gene ID: 617078, updated on 27-Dec-2024

    Summary

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    Official Symbol
    TRIM37provided by VGNC
    Official Full Name
    tripartite motif containing 37provided by VGNC
    Primary source
    VGNC:VGNC:36332
    See related
    Ensembl:ENSBTAG00000021677
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See TRIM37 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (9938260..10089721, complement)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene putative teratocarcinoma-derived growth factor 3 Neighboring gene RAD51 paralog C Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1E Neighboring gene U6 spliceosomal RNA Neighboring gene cytochrome c-like Neighboring gene spindle and kinetochore associated complex subunit 2 Neighboring gene microRNA mir-301a Neighboring gene microRNA mir-454

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC159446

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of centriole replication IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein autoubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in aggresome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRIM37
    Names
    tripartite motif-containing 37 protein
    NP_001103652.1
    XP_005219991.1
    XP_024836246.1
    XP_024836247.1
    XP_024836248.1
    XP_024836249.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110182.1 → NP_001103652.1  E3 ubiquitin-protein ligase TRIM37

      See identical proteins and their annotated locations for NP_001103652.1

      Status: PROVISIONAL

      Source sequence(s)
      BC154401
      UniProtKB/TrEMBL
      A0A3Q1MEF3, A8WFQ1
      Related
      ENSBTAP00000078910.1, ENSBTAT00000113794.1
      Conserved Domains (4) summary
      smart00502
      Location:132 → 254
      BBC; B-Box C-terminal domain
      cd00162
      Location:15 → 58
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd03773
      Location:273 → 406
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      pfam00643
      Location:90 → 132
      zf-B_box; B-box zinc finger

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      9938260..10089721 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024980481.2 → XP_024836249.1  E3 ubiquitin-protein ligase TRIM37 isoform X5

      UniProtKB/TrEMBL
      A0AAA9S1M2
      Conserved Domains (4) summary
      smart00502
      Location:132 → 254
      BBC; B-Box C-terminal domain
      cl02446
      Location:273 → 344
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      pfam00643
      Location:90 → 132
      zf-B_box; B-box zinc finger
      cd16619
      Location:13 → 55
      mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins

    2. XM_005219934.4 → XP_005219991.1  E3 ubiquitin-protein ligase TRIM37 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1MEF3, A0AAA9SXF6
      Related
      ENSBTAP00000088759.1, ENSBTAT00000131858.1
      Conserved Domains (4) summary
      smart00502
      Location:132 → 254
      BBC; B-Box C-terminal domain
      cd00162
      Location:15 → 58
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd03773
      Location:273 → 406
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      pfam00643
      Location:90 → 132
      zf-B_box; B-box zinc finger

    3. XM_024980480.1 → XP_024836248.1  E3 ubiquitin-protein ligase TRIM37 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MEF3, E1BGD4
      Related
      ENSBTAP00000035393.5, ENSBTAT00000035518.6
      Conserved Domains (4) summary
      smart00502
      Location:132 → 254
      BBC; B-Box C-terminal domain
      cd03773
      Location:273 → 428
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      pfam00643
      Location:90 → 132
      zf-B_box; B-box zinc finger
      cd16619
      Location:13 → 55
      mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins

    4. XM_024980478.2 → XP_024836246.1  E3 ubiquitin-protein ligase TRIM37 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MEF3
      Conserved Domains (4) summary
      smart00502
      Location:132 → 254
      BBC; B-Box C-terminal domain
      cd03773
      Location:273 → 428
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      pfam00643
      Location:90 → 132
      zf-B_box; B-box zinc finger
      cd16619
      Location:13 → 55
      mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins

    5. XM_024980479.2 → XP_024836247.1  E3 ubiquitin-protein ligase TRIM37 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1MEF3, E1BGD4
      Conserved Domains (4) summary
      smart00502
      Location:132 → 254
      BBC; B-Box C-terminal domain
      cd03773
      Location:273 → 428
      MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
      pfam00643
      Location:90 → 132
      zf-B_box; B-box zinc finger
      cd16619
      Location:13 → 55
      mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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