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    NRDC nardilysin convertase [ Bos taurus (domestic cattle) ]

    Gene ID: 511254, updated on 30-Jan-2025

    Summary

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    Official Symbol
    NRDCprovided by VGNC
    Official Full Name
    nardilysin convertaseprovided by VGNC
    Primary source
    VGNC:VGNC:32258
    See related
    BGD:BT21229; EnsemblRapid:ENSBTAG00070004117
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    NRD1
    Orthologs
    human mouse all
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    Genomic context

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    See NRDC in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (94437449..94540297)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene thioredoxin domain containing 12 Neighboring gene KTI12 chromatin associated homolog Neighboring gene RAB3B, member RAS oncogene family Neighboring gene transfer RNA tyrosine (anticodon GUA) Neighboring gene microRNA mir-761 Neighboring gene microRNA mir-11991 Neighboring gene oxysterol binding protein like 9 Neighboring gene transfer RNA tryptophan (anticodon CCA)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nardilysin
    Names
    nardilysin (N-arginine dibasic convertase)
    NP_001193920.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206991.1 → NP_001193920.1  nardilysin

      Status: VALIDATED

      Source sequence(s)
      DT834452, DV915014, DV918840, DY044547, DY087026, EE244937, EH168759, EV622613, NKLS02000003
      UniProtKB/TrEMBL
      A0A3Q1LY70
      Related
      ENSBTAP00070005187.1, ENSBTAT00070009323.1
      Conserved Domains (5) summary
      pfam06019
      Location:1094 → 1153
      Phage_30_8; Phage GP30.8 protein
      COG1025
      Location:291 → 1169
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
      pfam00675
      Location:291 → 417
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:442 → 628
      Peptidase_M16_C; Peptidase M16 inactive domain
      pfam16187
      Location:633 → 914
      Peptidase_M16_M; Middle or third domain of peptidase_M16

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      94437449..94540297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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