CAPN2 calpain 2 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: CAPN2provided by VGNC
Official Full Name: calpain 2provided by VGNC
Primary source: VGNC:VGNC:55037
See related: BGD:BT28303; EnsemblRapid:ENSBTAG00070009540
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	16	NC_037343.1 (27080007..27138329)

Chromosome 16 - NC_037343.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

m- and micro-calpain immunosignals in the cytoplasm both along the Z disk/I band regions and in the form of intracellular stores.
Title: Immunological detection of m- and µ-calpains in the skeletal muscle of Marchigiana cattle.
The objective of this study was to estimate the allele and genotype frequencies of the IGF-IR/TaqI, m-calpain/HhaI, and UCP-3/BglI polymorphisms and to determine association between these polymorphisms and growth traits in Chinese indigenous cattle breed.
Title: Association between IGF-IR, m-calpain and UCP-3 gene polymorphisms and growth traits in Nanyang cattle.
The cleavage of NCX1 by m-calpain in the caveolae vesicles may be interpreted as an important mechanism of Ca(2+) overload
Title: m-Calpain-mediated cleavage of Na+/Ca2+ exchanger-1 in caveolae vesicles isolated from pulmonary artery smooth muscle.
characteristic properties of ER membrane m-calpain (MCp), calpastatins and lumen m-calpain (LCp) and a brief comparative study between MCp and LCp
Title: Characteristic properties of endoplasmic reticulum membrane m-calpain, calpastatin and lumen m-calpain: a comparative study between membrane and lumen m-calpains.

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General gene information

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Markers

MARC_33658-33659:1063998920:1 (e-PCR)
- UniSTS:269248

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium-dependent cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: calpain-2 catalytic subunit

Names: CANP 2; M-calpain; calcium-activated neutral proteinase 2; calpain 2, (m/II) large subunit; calpain M-type; calpain, large polypeptide L2; calpain-2 large subunit; millimolar-calpain

NP_001096556.1

EC 3.4.22.53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001103086.1 → NP_001096556.1 calpain-2 catalytic subunit

See identical proteins and their annotated locations for NP_001096556.1

Status: PROVISIONAL

Source sequence(s)

BC134526

UniProtKB/Swiss-Prot

A4IFD3, Q27971

UniProtKB/TrEMBL

A0A3Q1LRZ7

Related

ENSBTAP00070012589.1, ENSBTAT00070021516.1

Conserved Domains (3) summary

pfam00648
Location:46 → 342

Peptidase_C2; Calpain family cysteine protease

pfam01067
Location:363 → 507

Calpain_III; Calpain large subunit, domain III

cd16199
Location:533 → 700

EFh_PEF_CAPN2; Penta-EF hand, calcium binding motifs, found in m-type calpain (CAPN2)