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    LTBP1 latent transforming growth factor beta binding protein 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 510559, updated on 27-Dec-2024

    Summary

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    Official Symbol
    LTBP1provided by VGNC
    Official Full Name
    latent transforming growth factor beta binding protein 1provided by VGNC
    Primary source
    VGNC:VGNC:31071
    See related
    Ensembl:ENSBTAG00000019839
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See LTBP1 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (15473629..15930112)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 27 Neighboring gene large ribosomal subunit protein eL6-like Neighboring gene RAS guanyl releasing protein 3 Neighboring gene family with sequence similarity 98 member A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Fibrillins and latent TGFbeta binding proteins in bovine ovaries of offspring following high or low protein diets during pregnancy of dams. Prodoehl MJ, et al. Mol Cell Endocrinol, 2009 Aug 13. PMID 19524133
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This is the first study to investigate the expression and localization of fibrillin proteins and latent TGF-beta binding proteins affecting TGFbeta bioavailability in the ovary.
      Title: Fibrillins and latent TGFbeta binding proteins in bovine ovaries of offspring following high or low protein diets during pregnancy of dams.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC166121

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    latent-transforming growth factor beta-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001103091.1 → NP_001096561.1  latent-transforming growth factor beta-binding protein 1 precursor

      See identical proteins and their annotated locations for NP_001096561.1

      Status: PROVISIONAL

      Source sequence(s)
      BC151354
      UniProtKB/TrEMBL
      A0A3Q1M8C7, A7YY58
      Conserved Domains (4) summary
      smart00179
      Location:821 → 862
      EGF_CA; Calcium-binding EGF-like domain
      pfam00683
      Location:361 → 395
      TB; TB domain
      pfam07645
      Location:534 → 574
      EGF_CA; Calcium-binding EGF domain
      pfam12662
      Location:515 → 537
      cEGF; Complement Clr-like EGF-like

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      15473629..15930112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024998486.2 → XP_024854254.1  latent-transforming growth factor beta-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LF45, F1N444
      Related
      ENSBTAP00000026435.6, ENSBTAT00000026435.7
      Conserved Domains (6) summary
      smart00179
      Location:1191 → 1232
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:987 → 1020
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00683
      Location:678 → 717
      TB; TB domain
      pfam07645
      Location:904 → 944
      EGF_CA; Calcium-binding EGF domain
      pfam12662
      Location:885 → 907
      cEGF; Complement Clr-like EGF-like
      cl26464
      Location:731 → 857
      Atrophin-1; Atrophin-1 family

    2. XM_024998488.2 → XP_024854256.1  latent-transforming growth factor beta-binding protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1LF45
      Conserved Domains (6) summary
      smart00179
      Location:1191 → 1232
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:987 → 1020
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00683
      Location:678 → 717
      TB; TB domain
      pfam07645
      Location:904 → 944
      EGF_CA; Calcium-binding EGF domain
      pfam12662
      Location:885 → 907
      cEGF; Complement Clr-like EGF-like
      cl26464
      Location:731 → 857
      Atrophin-1; Atrophin-1 family

    3. XM_024998487.2 → XP_024854255.1  latent-transforming growth factor beta-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LF45
      Conserved Domains (6) summary
      smart00179
      Location:1190 → 1231
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:986 → 1019
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00683
      Location:678 → 717
      TB; TB domain
      pfam07645
      Location:903 → 943
      EGF_CA; Calcium-binding EGF domain
      pfam12662
      Location:884 → 906
      cEGF; Complement Clr-like EGF-like
      cl27169
      Location:740 → 858
      ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...

    4. XM_024998489.2 → XP_024854257.1  latent-transforming growth factor beta-binding protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1LF45
      Related
      ENSBTAP00000071114.2, ENSBTAT00000086953.2
      Conserved Domains (5) summary
      smart00179
      Location:1138 → 1179
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:934 → 967
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00683
      Location:1293 → 1334
      TB; TB domain
      pfam07645
      Location:851 → 891
      EGF_CA; Calcium-binding EGF domain
      pfam12662
      Location:832 → 854
      cEGF; Complement Clr-like EGF-like

    5. XM_024998492.2 → XP_024854260.1  latent-transforming growth factor beta-binding protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A3Q1LF45, F1MJM5
      Related
      ENSBTAP00000049409.4, ENSBTAT00000055559.4
      Conserved Domains (5) summary
      smart00179
      Location:1138 → 1179
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:934 → 967
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00683
      Location:1251 → 1292
      TB; TB domain
      pfam07645
      Location:851 → 891
      EGF_CA; Calcium-binding EGF domain
      pfam12662
      Location:832 → 854
      cEGF; Complement Clr-like EGF-like

    6. XM_024998490.2 → XP_024854258.1  latent-transforming growth factor beta-binding protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A3Q1LF45
      Conserved Domains (5) summary
      smart00179
      Location:1137 → 1178
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:933 → 966
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00683
      Location:1292 → 1333
      TB; TB domain
      pfam07645
      Location:850 → 890
      EGF_CA; Calcium-binding EGF domain
      pfam12662
      Location:831 → 853
      cEGF; Complement Clr-like EGF-like

    7. XM_024998491.2 → XP_024854259.1  latent-transforming growth factor beta-binding protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A3Q1LF45
      Related
      ENSBTAP00000056685.2, ENSBTAT00000085972.2
      Conserved Domains (6) summary
      smart00179
      Location:1135 → 1176
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:931 → 964
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00683
      Location:622 → 661
      TB; TB domain
      pfam07645
      Location:848 → 888
      EGF_CA; Calcium-binding EGF domain
      pfam12662
      Location:829 → 851
      cEGF; Complement Clr-like EGF-like
      cl26464
      Location:675 → 801
      Atrophin-1; Atrophin-1 family

    8. XM_059891159.1 → XP_059747142.1  latent-transforming growth factor beta-binding protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A3Q1M8C7

    9. XM_024998493.2 → XP_024854261.1  latent-transforming growth factor beta-binding protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A3Q1M8C7
      Conserved Domains (6) summary
      smart00179
      Location:874 → 915
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:670 → 703
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00683
      Location:361 → 400
      TB; TB domain
      pfam07645
      Location:587 → 627
      EGF_CA; Calcium-binding EGF domain
      pfam12662
      Location:568 → 590
      cEGF; Complement Clr-like EGF-like
      cl26464
      Location:414 → 540
      Atrophin-1; Atrophin-1 family

    10. XM_059891160.1 → XP_059747143.1  latent-transforming growth factor beta-binding protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A3Q1M8C7

    11. XM_059891161.1 → XP_059747144.1  latent-transforming growth factor beta-binding protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A3Q1M8C7

    12. XM_024998494.2 → XP_024854262.1  latent-transforming growth factor beta-binding protein 1 isoform X13

      UniProtKB/TrEMBL
      A0A3Q1M8C7
      Conserved Domains (5) summary
      smart00179
      Location:821 → 862
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:617 → 650
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00683
      Location:934 → 975
      TB; TB domain
      pfam07645
      Location:534 → 574
      EGF_CA; Calcium-binding EGF domain
      pfam12662
      Location:515 → 537
      cEGF; Complement Clr-like EGF-like

    13. XM_059891162.1 → XP_059747145.1  latent-transforming growth factor beta-binding protein 1 isoform X12

      UniProtKB/TrEMBL
      A0A3Q1M8C7
      Related
      ENSBTAP00000064681.2, ENSBTAT00000077023.2

    14. XM_059891163.1 → XP_059747146.1  latent-transforming growth factor beta-binding protein 1 isoform X14

      UniProtKB/TrEMBL
      A0A3Q1M8C7
    Nucleotide Protein Strain
    Heading Accession and Version

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