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    ARHGEF5 Rho guanine nucleotide exchange factor 5 [ Bos taurus (domestic cattle) ]

    Gene ID: 516290, updated on 30-Jan-2025

    Summary

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    Official Symbol
    ARHGEF5provided by VGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 5provided by VGNC
    Primary source
    VGNC:VGNC:26119
    See related
    BGD:BT29603; EnsemblRapid:ENSBTAG00070032514
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ARHGEF5 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (107620223..107650871)

    Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily A member 62 Neighboring gene olfactory receptor family 2 subfamily A member 63, pseudogene Neighboring gene NOBOX oogenesis homeobox Neighboring gene uncharacterized LOC112446451 Neighboring gene thiamin pyrophosphokinase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC138953

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 5
    Names
    Rho guanine nucleotide exchange factor (GEF) 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110075.2 → NP_001103545.2  rho guanine nucleotide exchange factor 5

      See identical proteins and their annotated locations for NP_001103545.2

      Status: VALIDATED

      Source sequence(s)
      BF042105, BI539326, CB440533, EE350207, NKLS02000004
      UniProtKB/TrEMBL
      F1N2G5
      Conserved Domains (5) summary
      cd11940
      Location:1501 → 1555
      SH3_ARHGEF5_19; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF5 and ARHGEF19
      cd01221
      Location:1365 → 1491
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00169
      Location:1378 → 1484
      PH; PH domain
      pfam00621
      Location:1167 → 1343
      RhoGEF; RhoGEF domain
      pfam15441
      Location:1 → 464
      ARHGEF5_35; Rho guanine nucleotide exchange factor 5/35

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      107620223..107650871
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005205839.4 → XP_005205896.1  rho guanine nucleotide exchange factor 5 isoform X1

      See identical proteins and their annotated locations for XP_005205896.1

      UniProtKB/TrEMBL
      F1N2G5
      Related
      ENSBTAP00070044806.1, ENSBTAT00070073525.1
      Conserved Domains (5) summary
      cd11940
      Location:1501 → 1555
      SH3_ARHGEF5_19; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF5 and ARHGEF19
      cd01221
      Location:1365 → 1491
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00169
      Location:1378 → 1484
      PH; PH domain
      pfam00621
      Location:1167 → 1343
      RhoGEF; RhoGEF domain
      pfam15441
      Location:1 → 464
      ARHGEF5_35; Rho guanine nucleotide exchange factor 5/35
    Nucleotide Protein Strain
    Heading Accession and Version

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    Research Materials