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    EIF2S1 eukaryotic translation initiation factor 2 subunit alpha [ Bos taurus (domestic cattle) ]

    Gene ID: 327694, updated on 1-Jan-2025

    Summary

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    Official Symbol
    EIF2S1provided by VGNC
    Official Full Name
    eukaryotic translation initiation factor 2 subunit alphaprovided by VGNC
    Primary source
    VGNC:VGNC:28390
    See related
    BGD:BT21081; Ensembl:ENSBTAG00000016311
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See EIF2S1 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (79255235..79278260)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene protein associated with LIN7 1, MAGUK p55 family member Neighboring gene ATPase H+ transporting V1 subunit D Neighboring gene pleckstrin 2 Neighboring gene small ribosomal subunit protein eS27-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Alterations in molecular chaperones and eIF2alpha during lung endothelial cell apoptosis. Lu Q, et al. Am J Physiol Lung Cell Mol Physiol, 2010 Apr. PMID 20097734, Free PMC Article
    2. Isolation and characterisation of a bovine cDNA encoding eukaryotic initiation factor 2 alpha. Green SR, et al. Biochim Biophys Acta, 1991 Oct 8. PMID 1932125
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Caspase(s)-dependent proteolysis of molecular chaperones and eIF2alpha may be novel signaling pathways of apoptosis.
      Title: Alterations in molecular chaperones and eIF2alpha during lung endothelial cell apoptosis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC128972

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 2 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 2 subunit 1
    Names
    EIF-2A
    EIF-2alpha
    eIF-2-alpha
    eIF2-alpha
    eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175813.2 → NP_787007.1  eukaryotic translation initiation factor 2 subunit 1

      See identical proteins and their annotated locations for NP_787007.1

      Status: PROVISIONAL

      Source sequence(s)
      BC104590
      UniProtKB/Swiss-Prot
      P05199, P68102, Q3SWZ1
      Related
      ENSBTAP00000040899.1, ENSBTAT00000043322.2
      Conserved Domains (1) summary
      PTZ00248
      Location:4 → 315
      PTZ00248; eukaryotic translation initiation factor 2 subunit 1; Provisional

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      79255235..79278260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005211941.4 → XP_005211998.1  eukaryotic translation initiation factor 2 subunit 1 isoform X1

      See identical proteins and their annotated locations for XP_005211998.1

      UniProtKB/Swiss-Prot
      P05199, P68102, Q3SWZ1
      Conserved Domains (1) summary
      PTZ00248
      Location:4 → 315
      PTZ00248; eukaryotic translation initiation factor 2 subunit 1; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P68102.2 GenPept UniProtKB/Swiss-Prot:P68102

    Gene LinkOut

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