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    MADD MAP kinase activating death domain [ Bos taurus (domestic cattle) ]

    Gene ID: 534306, updated on 30-Jan-2025

    Summary

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    Official Symbol
    MADDprovided by VGNC
    Official Full Name
    MAP kinase activating death domainprovided by VGNC
    Primary source
    VGNC:VGNC:31134
    See related
    BGD:BT14610; EnsemblRapid:ENSBTAG00070031920
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See MADD in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (77140136..77180691)

    Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene damage specific DNA binding protein 2 Neighboring gene acid phosphatase 2, lysosomal Neighboring gene nuclear receptor subfamily 1 group H member 3 Neighboring gene microRNA mir-2318 Neighboring gene myosin binding protein C3 Neighboring gene Spi-1 proto-oncogene

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of Rab protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MAP kinase-activating death domain protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193078.1 → NP_001180007.1  MAP kinase-activating death domain protein

      See identical proteins and their annotated locations for NP_001180007.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000015
      UniProtKB/TrEMBL
      A0A3Q1LK83, E1BK67
      Related
      ENSBTAP00070044137.1, ENSBTAT00070072387.1
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      77140136..77180691
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059874796.1 → XP_059730779.1  MAP kinase-activating death domain protein isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LK83, E1BK67
      Related
      ENSBTAP00070044234.1, ENSBTAT00070072606.1

    2. XM_059874806.1 → XP_059730789.1  MAP kinase-activating death domain protein isoform X8

      UniProtKB/TrEMBL
      E1BK67

    3. XM_059874799.1 → XP_059730782.1  MAP kinase-activating death domain protein isoform X2

      UniProtKB/TrEMBL
      E1BK67

    4. XM_059874800.1 → XP_059730783.1  MAP kinase-activating death domain protein isoform X3

      UniProtKB/TrEMBL
      E1BK67

    5. XM_059874802.1 → XP_059730785.1  MAP kinase-activating death domain protein isoform X5

      UniProtKB/TrEMBL
      E1BK67

    6. XM_059874811.1 → XP_059730794.1  MAP kinase-activating death domain protein isoform X13

      UniProtKB/TrEMBL
      E1BK67
      Related
      ENSBTAP00070044369.1, ENSBTAT00070072864.1

    7. XM_059874803.1 → XP_059730786.1  MAP kinase-activating death domain protein isoform X6

      UniProtKB/TrEMBL
      E1BK67

    8. XM_059874807.1 → XP_059730790.1  MAP kinase-activating death domain protein isoform X9

      UniProtKB/TrEMBL
      E1BK67

    9. XM_024975366.2 → XP_024831134.1  MAP kinase-activating death domain protein isoform X16

      UniProtKB/TrEMBL
      A0AAA9S140, E1BK67
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    10. XM_059874804.1 → XP_059730787.1  MAP kinase-activating death domain protein isoform X7

      UniProtKB/TrEMBL
      E1BK67

    11. XM_059874808.1 → XP_059730791.1  MAP kinase-activating death domain protein isoform X10

      UniProtKB/TrEMBL
      E1BK67
      Related
      ENSBTAP00070044336.1, ENSBTAT00070072806.1

    12. XM_059874810.1 → XP_059730793.1  MAP kinase-activating death domain protein isoform X12

      UniProtKB/TrEMBL
      E1BK67

    13. XM_059874817.1 → XP_059730800.1  MAP kinase-activating death domain protein isoform X19

      UniProtKB/TrEMBL
      E1BK67

    14. XM_059874812.1 → XP_059730795.1  MAP kinase-activating death domain protein isoform X14

      UniProtKB/TrEMBL
      E1BK67

    15. XM_059874819.1 → XP_059730802.1  MAP kinase-activating death domain protein isoform X21

      UniProtKB/TrEMBL
      E1BK67

    16. XM_059874813.1 → XP_059730796.1  MAP kinase-activating death domain protein isoform X15

      UniProtKB/TrEMBL
      E1BK67

    17. XM_059874814.1 → XP_059730797.1  MAP kinase-activating death domain protein isoform X17

      UniProtKB/TrEMBL
      E1BK67

    18. XM_059874818.1 → XP_059730801.1  MAP kinase-activating death domain protein isoform X20

      UniProtKB/TrEMBL
      E1BK67

    19. XM_059874827.1 → XP_059730810.1  MAP kinase-activating death domain protein isoform X29

      UniProtKB/TrEMBL
      E1BK67

    20. XM_059874821.1 → XP_059730804.1  MAP kinase-activating death domain protein isoform X23

      UniProtKB/TrEMBL
      E1BK67

    21. XM_059874830.1 → XP_059730813.1  MAP kinase-activating death domain protein isoform X32

      UniProtKB/TrEMBL
      E1BK67

    22. XM_059874820.1 → XP_059730803.1  MAP kinase-activating death domain protein isoform X22

      UniProtKB/TrEMBL
      E1BK67

    23. XM_059874822.1 → XP_059730805.1  MAP kinase-activating death domain protein isoform X24

      UniProtKB/TrEMBL
      E1BK67

    24. XM_059874826.1 → XP_059730809.1  MAP kinase-activating death domain protein isoform X28

      UniProtKB/TrEMBL
      E1BK67

    25. XM_059874834.1 → XP_059730817.1  MAP kinase-activating death domain protein isoform X36

      UniProtKB/TrEMBL
      E1BK67

    26. XM_059874828.1 → XP_059730811.1  MAP kinase-activating death domain protein isoform X30

      UniProtKB/TrEMBL
      E1BK67

    27. XM_015474920.3 → XP_015330406.1  MAP kinase-activating death domain protein isoform X37

      UniProtKB/TrEMBL
      E1BK67
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    28. XM_059874801.1 → XP_059730784.1  MAP kinase-activating death domain protein isoform X4

      UniProtKB/TrEMBL
      E1BK67

    29. XM_059874809.1 → XP_059730792.1  MAP kinase-activating death domain protein isoform X11

      UniProtKB/TrEMBL
      E1BK67

    30. XM_059874797.1 → XP_059730780.1  MAP kinase-activating death domain protein isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LK83, E1BK67

    31. XM_059874823.1 → XP_059730806.1  MAP kinase-activating death domain protein isoform X25

      UniProtKB/TrEMBL
      A0A3Q1MA83, E1BK67

    32. XM_059874824.1 → XP_059730807.1  MAP kinase-activating death domain protein isoform X26

      UniProtKB/TrEMBL
      E1BK67

    33. XM_024975371.2 → XP_024831139.1  MAP kinase-activating death domain protein isoform X27

      UniProtKB/TrEMBL
      E1BK67
      Related
      ENSBTAP00070044262.1, ENSBTAT00070072663.1
      Conserved Domains (3) summary
      smart00801
      Location:486 → 554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173 → 402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:8 → 98
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    34. XM_059874829.1 → XP_059730812.1  MAP kinase-activating death domain protein isoform X31

      UniProtKB/TrEMBL
      A0AAA9S059

    35. XM_059874832.1 → XP_059730815.1  MAP kinase-activating death domain protein isoform X34

      UniProtKB/TrEMBL
      A0AAA9S059

    36. XM_059874831.1 → XP_059730814.1  MAP kinase-activating death domain protein isoform X33

      UniProtKB/TrEMBL
      A0AAA9S059

    37. XM_059874833.1 → XP_059730816.1  MAP kinase-activating death domain protein isoform X35

      UniProtKB/TrEMBL
      A0AAA9S059

    38. XM_059874835.1 → XP_059730818.1  MAP kinase-activating death domain protein isoform X38

      UniProtKB/TrEMBL
      A0AAA9S059

    39. XM_059874836.1 → XP_059730819.1  MAP kinase-activating death domain protein isoform X39

      UniProtKB/TrEMBL
      E1BK67

    40. XM_059874837.1 → XP_059730820.1  MAP kinase-activating death domain protein isoform X40

      UniProtKB/TrEMBL
      E1BK67

    41. XM_059874838.1 → XP_059730821.1  MAP kinase-activating death domain protein isoform X41

      UniProtKB/TrEMBL
      E1BK67

    42. XM_059874839.1 → XP_059730822.1  MAP kinase-activating death domain protein isoform X42

      UniProtKB/TrEMBL
      A0AAA9S059

    43. XM_059874841.1 → XP_059730824.1  MAP kinase-activating death domain protein isoform X44

      UniProtKB/TrEMBL
      A0AAA9S059

    44. XM_059874840.1 → XP_059730823.1  MAP kinase-activating death domain protein isoform X43

      UniProtKB/TrEMBL
      A0AAA9S059

    45. XM_059874842.1 → XP_059730825.1  MAP kinase-activating death domain protein isoform X45

      UniProtKB/TrEMBL
      A0AAA9S059

    46. XM_059874843.1 → XP_059730826.1  MAP kinase-activating death domain protein isoform X46

      UniProtKB/TrEMBL
      A0AAA9S059

    47. XM_059874844.1 → XP_059730827.1  MAP kinase-activating death domain protein isoform X47

      UniProtKB/TrEMBL
      A0AAA9S059

    48. XM_059874816.1 → XP_059730799.1  MAP kinase-activating death domain protein isoform X18

      UniProtKB/TrEMBL
      E1BK67

    49. XM_059874815.1 → XP_059730798.1  MAP kinase-activating death domain protein isoform X18

      UniProtKB/TrEMBL
      E1BK67

    50. XM_059874798.1 → XP_059730781.1  MAP kinase-activating death domain protein isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LK83, E1BK67
    Nucleotide Protein Strain
    Heading Accession and Version

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