ANXA1 annexin A1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: ANXA1provided by VGNC
Official Full Name: annexin A1provided by VGNC
Primary source: VGNC:VGNC:50196
See related: EnsemblRapid:ENSBTAG00070004177
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: p35
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	8	NC_037335.1 (49321701..49339582)

Chromosome 8 - NC_037335.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WISP1 promotes bovine MDSC differentiation via recruitment of ANXA1 for the regulation of the TGF-beta signalling pathway.
Title: WISP1 promotes bovine MDSC differentiation via recruitment of ANXA1 for the regulation of the TGF-β signalling pathway.
Annexins A1 and A2 are proteins produced by airway epithelial cells that may prevent inflammation in the healthy lung and be relevant to development of pneumonia in stressed cattle.
Title: Localization of annexins A1 and A2 in the respiratory tract of healthy calves and those experimentally infected with Mannheimia haemolytica.
Calves that later developed pneumonia had significantly lower levels of annexin A1 and annexin A2, which are potential biomarkers of increased susceptibility to pneumonia in recently weaned and transported feedlot cattle.
Title: Increased annexin A1 and A2 levels in bronchoalveolar lavage fluid are associated with resistance to respiratory disease in beef calves.
Ubiquitination of annexin A1 may play an important role in mutagenesis, an initial step of cell transformation.
Title: Ubiquitination and SUMOylation of annexin A1 and helicase activity.
Because annexins I and II are abundant and have functions important to the maintenance of placentation, the down-regulation of the annexin genes in the cultured NT (nuclear transfer)trophectoderm may be related to the frequent failures of NT pregnancies.
Title: Proteomic analysis of the major cellular proteins of bovine trophectoderm cell lines derived from IVP, parthenogenetic and nuclear transfer embryos: Reduced expression of annexins I and II in nuclear transfer-derived cell lines.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cadherin binding involved in cell-cell adhesion	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium-dependent phospholipid binding	IEA Inferred from Electronic Annotation more info	PubMed
enables phospholipase A2 inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	IEA Inferred from Electronic Annotation more info	PubMed
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in alpha-beta T cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in arachidonate secretion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to glucocorticoid stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to vascular endothelial growth factor stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in endocrine pancreas development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in estrous cycle	IEA Inferred from Electronic Annotation more info	PubMed
involved_in gliogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in granulocyte chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in hepatocyte differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in insulin secretion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in keratinocyte differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in myoblast migration involved in skeletal muscle regeneration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of T-helper 2 cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of exocytosis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of phospholipase A2 activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neutrophil clearance	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of T-helper 1 cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell migration involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of interleukin-2 production	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of neutrophil apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of prostaglandin biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of vesicle fusion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of wound healing	IEA Inferred from Electronic Annotation more info	PubMed
involved_in prolactin secretion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in prostate gland development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of hormone secretion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of interleukin-1 production	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of leukocyte migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to X-ray	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to interleukin-1	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to peptide hormone	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: annexin A1

Names: annexin I; annexin-1; calpactin II; calpactin-2; chromobindin-9; lipocortin I; phospholipase A2 inhibitory protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.