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    PARN poly(A)-specific ribonuclease [ Bos taurus (domestic cattle) ]

    Gene ID: 524155, updated on 30-Jan-2025

    Summary

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    Gene symbol
    PARN
    Gene description
    poly(A)-specific ribonuclease
    See related
    BGD:BT16176; EnsemblRapid:ENSBTAG00070024048
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PARN in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 25 NC_037352.1 (13363053..13542409, complement)

    Chromosome 25 - NC_037352.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100849865 Neighboring gene uncharacterized LOC132343844 Neighboring gene microRNA mir-365-1 Neighboring gene bifunctional apoptosis regulator Neighboring gene group 10 secretory phospholipase A2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037352.1 Chromosome 25 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Cap-dependent deadenylation of mRNA. Dehlin E, et al. EMBO J, 2000 Mar 1. PMID 10698948, Free PMC Article
    2. Poly(A) tail shortening by a mammalian poly(A)-specific 3'-exoribonuclease. Körner CG, et al. J Biol Chem, 1997 Apr 18. PMID 9099687
    3. The deadenylating nuclease (DAN) is involved in poly(A) tail removal during the meiotic maturation of Xenopus oocytes. Körner CG, et al. EMBO J, 1998 Sep 15. PMID 9736620, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables poly(A)-specific ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    poly(A)-specific ribonuclease PARN
    Names
    deadenylating nuclease
    deadenylation nuclease
    poly(A)-specific ribonuclease (deadenylation nuclease)
    polyadenylate-specific ribonuclease
    NP_001094588.1
    XP_010817608.1
    XP_010817609.1
    XP_010817610.1
    XP_010817611.1
    XP_024840680.1
    XP_059737315.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101118.2 → NP_001094588.1  poly(A)-specific ribonuclease PARN

      See identical proteins and their annotated locations for NP_001094588.1

      Status: PROVISIONAL

      Source sequence(s)
      BC150015
      UniProtKB/Swiss-Prot
      A6QQW2, P69341
      UniProtKB/TrEMBL
      A0A452DIW9
      Related
      ENSBTAP00070032601.1, ENSBTAT00070054451.1
      Conserved Domains (2) summary
      pfam04857
      Location:3 → 390
      CAF1; CAF1 family ribonuclease
      pfam08675
      Location:438 → 512
      RNA_bind; RNA binding domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037352.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      13363053..13542409 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024984912.2 → XP_024840680.1  poly(A)-specific ribonuclease PARN isoform X3

      UniProtKB/TrEMBL
      A0A452DIW9
      Conserved Domains (2) summary
      pfam08675
      Location:412 → 486
      RNA_bind; RNA binding domain
      pfam04857
      Location:3 → 364
      CAF1; CAF1 family ribonuclease

    2. XM_010819307.4 → XP_010817609.1  poly(A)-specific ribonuclease PARN isoform X2

      UniProtKB/TrEMBL
      A0A452DIW9
      Conserved Domains (2) summary
      pfam04857
      Location:3 → 414
      CAF1; CAF1 family ribonuclease
      cl17169
      Location:462 → 511
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. XM_010819306.4 → XP_010817608.1  poly(A)-specific ribonuclease PARN isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M3Q2, A0A452DIW9
      Related
      ENSBTAP00070032591.1, ENSBTAT00070054432.1
      Conserved Domains (2) summary
      pfam04857
      Location:3 → 414
      CAF1; CAF1 family ribonuclease
      pfam08675
      Location:462 → 536
      RNA_bind; RNA binding domain

    4. XM_010819309.4 → XP_010817611.1  poly(A)-specific ribonuclease PARN isoform X6

      UniProtKB/TrEMBL
      A0A3Q1MTZ7
      Conserved Domains (2) summary
      pfam08675
      Location:395 → 469
      RNA_bind; RNA binding domain
      pfam04857
      Location:11 → 347
      CAF1; CAF1 family ribonuclease

    5. XM_010819308.4 → XP_010817610.1  poly(A)-specific ribonuclease PARN isoform X5

      UniProtKB/TrEMBL
      A0A3Q1MTZ7
      Conserved Domains (2) summary
      pfam04857
      Location:1 → 353
      CAF1; CAF1 family ribonuclease
      pfam08675
      Location:401 → 475
      RNA_bind; RNA binding domain

    6. XM_059881332.1 → XP_059737315.1  poly(A)-specific ribonuclease PARN isoform X4

      UniProtKB/TrEMBL
      A0AAA9SG57
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P69341.2 GenPept UniProtKB/Swiss-Prot:P69341

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