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    NCALD neurocalcin delta [ Bos taurus (domestic cattle) ]

    Gene ID: 281940, updated on 1-Jan-2025

    Summary

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    Official Symbol
    NCALDprovided by VGNC
    Official Full Name
    neurocalcin deltaprovided by VGNC
    Primary source
    VGNC:VGNC:31897
    See related
    BGD:BT25495; Ensembl:ENSBTAG00000026963
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See NCALD in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 14 NC_037341.1 (62246632..62715291)

    Chromosome 14 - NC_037341.1Genomic Context describing neighboring genes Neighboring gene ubiquitin protein ligase E3 component n-recognin 5 Neighboring gene U6 spliceosomal RNA Neighboring gene ribonucleotide reductase regulatory TP53 inducible subunit M2B Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC101904656 Neighboring gene grainyhead like transcription factor 2 Neighboring gene transfer RNA tryptophan (anticodon CCA)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037341.1 Chromosome 14 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Structural, biochemical, and functional characterization of the calcium sensor neurocalcin delta in the inner retinal neurons and its linkage with the rod outer segment membrane guanylate cyclase transduction system. Krishnan A, et al. Biochemistry, 2004 Mar 16. PMID 15005606
    2. Crystal structure of recombinant bovine neurocalcin. Vijay-Kumar S, et al. Nat Struct Biol, 1999 Jan. PMID 9886296
    3. Crystallization and preliminary X-ray crystallographic studies of recombinant bovine neurocalcin delta. Kumar VD, et al. Proteins, 1996 Jun. PMID 8811741
    4. Calcium and membrane binding properties of bovine neurocalcin delta expressed in Escherichia coli. Ladant D. J Biol Chem, 1995 Feb 17. PMID 7852401
    5. Full sequence of neurocalcin, a novel calcium-binding protein abundant in central nervous system. Okazaki K, et al. Biochem Biophys Res Commun, 1992 May 29. PMID 1599450

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neurocalcin delta modulates the Ca2+-modulated membrane guanylate cyclase transduction system in the neurons of the retinal inner plexiform layer.
      Title: Structural, biochemical, and functional characterization of the calcium sensor neurocalcin delta in the inner retinal neurons and its linkage with the rod outer segment membrane guanylate cyclase transduction system.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC139617

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neurocalcin-delta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359911.1 → NP_001346840.1  neurocalcin-delta

      Status: VALIDATED

      Source sequence(s)
      DAAA02039339, DAAA02039341, DT899793, DV826731, EH144443, EH147775, EH153129, EH200876
      UniProtKB/Swiss-Prot
      A1L533, P61602, Q0IIL3
      Related
      ENSBTAP00000069878.1, ENSBTAT00000068404.1
      Conserved Domains (1) summary
      COG5126
      Location:14 → 179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    2. NM_001359912.1 → NP_001346841.1  neurocalcin-delta

      Status: VALIDATED

      Source sequence(s)
      DT899793, DV826731, EE227229, EH144443, EH147775, EH153129, EH200876, NKLS02000014
      UniProtKB/Swiss-Prot
      A1L533, P61602, Q0IIL3
      Conserved Domains (1) summary
      COG5126
      Location:14 → 179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    3. NM_174398.3 → NP_776823.1  neurocalcin-delta

      See identical proteins and their annotated locations for NP_776823.1

      Status: VALIDATED

      Source sequence(s)
      DT899793, DV826731, EH144443, EH147775, EH153129, EH200876, NKLS02000014
      UniProtKB/Swiss-Prot
      A1L533, P61602, Q0IIL3
      Conserved Domains (1) summary
      COG5126
      Location:14 → 179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037341.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      62246632..62715291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025001407.2 → XP_024857175.1  neurocalcin-delta isoform X1

      UniProtKB/Swiss-Prot
      A1L533, P61602, Q0IIL3
      Conserved Domains (1) summary
      COG5126
      Location:14 → 179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    2. XM_025001408.2 → XP_024857176.1  neurocalcin-delta isoform X1

      UniProtKB/Swiss-Prot
      A1L533, P61602, Q0IIL3
      Conserved Domains (1) summary
      COG5126
      Location:14 → 179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    3. XM_059893125.1 → XP_059749108.1  neurocalcin-delta isoform X1

      UniProtKB/Swiss-Prot
      A1L533, P61602, Q0IIL3

    4. XM_025001409.2 → XP_024857177.1  neurocalcin-delta isoform X1

      UniProtKB/Swiss-Prot
      A1L533, P61602, Q0IIL3
      Conserved Domains (1) summary
      COG5126
      Location:14 → 179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    5. XM_025001406.2 → XP_024857174.1  neurocalcin-delta isoform X1

      UniProtKB/Swiss-Prot
      A1L533, P61602, Q0IIL3
      Conserved Domains (1) summary
      COG5126
      Location:14 → 179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    6. XM_015474513.3 → XP_015329999.1  neurocalcin-delta isoform X1

      UniProtKB/Swiss-Prot
      A1L533, P61602, Q0IIL3
      Conserved Domains (1) summary
      COG5126
      Location:14 → 179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    7. XM_005215613.5 → XP_005215670.1  neurocalcin-delta isoform X1

      See identical proteins and their annotated locations for XP_005215670.1

      UniProtKB/Swiss-Prot
      A1L533, P61602, Q0IIL3
      Conserved Domains (1) summary
      COG5126
      Location:14 → 179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61602.2 GenPept UniProtKB/Swiss-Prot:P61602

    Gene LinkOut

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