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    P2RX7 purinergic receptor P2X 7 [ Bos taurus (domestic cattle) ]

    Gene ID: 286814, updated on 1-Jan-2025

    Summary

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    Official Symbol
    P2RX7provided by VGNC
    Official Full Name
    purinergic receptor P2X 7provided by VGNC
    Primary source
    VGNC:VGNC:32522
    See related
    BGD:BT12438; Ensembl:ENSBTAG00000008948
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See P2RX7 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 17 NC_037344.1 (53966929..54027496, complement)

    Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132342549 Neighboring gene purinergic receptor P2X 4 Neighboring gene small ribosomal subunit protein uS14-like Neighboring gene intraflagellar transport 81 Neighboring gene transfer RNA tryptophan (anticodon CCA)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Inflammasome activation in bovine monocytes by extracellular ATP does not require the purinergic receptor P2X7. Hussen J, et al. Dev Comp Immunol, 2012 Oct. PMID 22728096
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables extracellularly ATP-gated monoatomic cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables purinergic nucleotide receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to ATP IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    P2X purinoceptor 7
    Names
    purinergic receptor P2X, ligand-gated ion channel, 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206516.1 → NP_001193445.1  P2X purinoceptor 7

      See identical proteins and their annotated locations for NP_001193445.1

      Status: VALIDATED

      Source sequence(s)
      NKLS02000017
      UniProtKB/TrEMBL
      F1MVZ6
      Related
      ENSBTAP00000011779.5, ENSBTAT00000011779.6
      Conserved Domains (1) summary
      pfam00864
      Location:11 → 397
      P2X_receptor; ATP P2X receptor

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      53966929..54027496 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005217740.5 → XP_005217797.1  P2X purinoceptor 7 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SA61
      Related
      ENSBTAP00000082208.1, ENSBTAT00000102706.1
      Conserved Domains (2) summary
      pfam00864
      Location:17 → 397
      P2X_receptor; ATP P2X receptor
      pfam14473
      Location:457 → 517
      RD3; RD3 protein
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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