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    SOST sclerostin [ Bos taurus (domestic cattle) ]

    Gene ID: 282880, updated on 27-Dec-2024

    Summary

    Official Symbol
    SOSTprovided by VGNC
    Official Full Name
    sclerostinprovided by VGNC
    Primary source
    VGNC:VGNC:35135
    See related
    BGD:BT12928
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
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    Genomic context

    See SOST in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (43644356..43649247, complement)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene mesenchyme homeobox 1 Neighboring gene uncharacterized LOC132342987 Neighboring gene dual specificity phosphatase 3 Neighboring gene CFAP97 domain containing 1 Neighboring gene MAGUK p55 scaffold protein 3

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Expression

    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    General gene information

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables BMP binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in negative regulation of Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in ossification IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Preferred Names
    sclerostin
    Names
    sclerosteosis

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166514.3NP_001159986.1  sclerostin precursor

      See identical proteins and their annotated locations for NP_001159986.1

      Status: VALIDATED

      Source sequence(s)
      AF326738, NKLS02000019
      UniProtKB/Swiss-Prot
      Q9BG79
      Conserved Domains (1) summary
      cl21545
      Location:1209
      GHB_like; Glycoprotein hormone beta chain homologues

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      43644356..43649247 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)