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    CD40 CD40 molecule [ Bos taurus (domestic cattle) ]

    Gene ID: 286849, updated on 1-Jan-2025

    Summary

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    Official Symbol
    CD40provided by VGNC
    Official Full Name
    CD40 moleculeprovided by VGNC
    Primary source
    VGNC:VGNC:27033
    See related
    BGD:BT10477; Ensembl:ENSBTAG00000020736
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    TNFRSF5
    Orthologs
    human mouse all
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    Genomic context

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    See CD40 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (74842418..74853117)

    Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 5 Neighboring gene uncharacterized LOC101904790 Neighboring gene small nucleolar RNA SNORD35 Neighboring gene transfer RNA glycine (anticodon UCC)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Cloning, expression and biological function of the bovine CD40 homologue: role in B-lymphocyte growth and differentiation in cattle. Hirano A, et al. Immunology, 1997 Feb. PMID 9135560, Free PMC Article
    2. Clinical disease upregulates expression of CD40 and CD40 ligand on peripheral blood mononuclear cells from cattle naturally infected with Mycobacterium avium subsp. paratuberculosis. Khalifeh MS, et al. Clin Vaccine Immunol, 2013 Aug. PMID 23761659, Free PMC Article
    3. Mycobacterium avium subspecies paratuberculosis suppresses expression of IL-12p40 and iNOS genes induced by signalling through CD40 in bovine monocyte-derived macrophages. Sommer S, et al. Vet Immunol Immunopathol, 2009 Mar 15. PMID 19022505
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results demonstrated greater CD40 and CD40L expression on fresh mononuclear leukocytes obtained from animals in the clinical stage of Johne's Disease.
      Title: Clinical disease upregulates expression of CD40 and CD40 ligand on peripheral blood mononuclear cells from cattle naturally infected with Mycobacterium avium subsp. paratuberculosis.
    2. study investigated the hypothesis that CD40 signalling is impaired in Mycobacterium avium subspecies paratuberculosis-infected macrophages
      Title: Mycobacterium avium subspecies paratuberculosis suppresses expression of IL-12p40 and iNOS genes induced by signalling through CD40 in bovine monocyte-derived macrophages.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC157138

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables antigen binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in B cell activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in CD40 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in TRIF-dependent toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to interleukin-1 IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response to protozoan IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response-regulating cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of blood vessel endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of endothelial cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of interleukin-12 production IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of isotype switching to IgG isotypes IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of tyrosine phosphorylation of STAT protein IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to type II interferon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CD40 receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tumor necrosis factor receptor superfamily member 5
    Names
    B-cell surface antigen CD40
    CD40 molecule, TNF receptor superfamily member 5
    CD40L receptor
    tumor necrosis factor receptor superfamily, member 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105611.2 → NP_001099081.1  tumor necrosis factor receptor superfamily member 5 precursor

      See identical proteins and their annotated locations for NP_001099081.1

      Status: PROVISIONAL

      Source sequence(s)
      BC134765
      UniProtKB/Swiss-Prot
      A7YWS9, Q28203
      UniProtKB/TrEMBL
      A0AAF6Z8L4
      Related
      ENSBTAP00000027630.7, ENSBTAT00000027630.7
      Conserved Domains (1) summary
      cd13407
      Location:26 → 186
      TNFRSF5; Tumor necrosis factor receptor superfamily member 5 (TNFRSF5), also known as CD40

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      74842418..74853117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015474118.3 → XP_015329604.2  tumor necrosis factor receptor superfamily member 5 isoform X2

      UniProtKB/TrEMBL
      A0AAA9SP45
      Related
      ENSBTAP00000085666.1, ENSBTAT00000129073.1
      Conserved Domains (1) summary
      cd13407
      Location:22 → 182
      TNFRSF5; Tumor necrosis factor receptor superfamily member 5 (TNFRSF5), also known as CD40

    2. XM_005214504.5 → XP_005214561.2  tumor necrosis factor receptor superfamily member 5 isoform X1

      UniProtKB/TrEMBL
      A0AAF6Z8L4
      Conserved Domains (1) summary
      cd13407
      Location:26 → 186
      TNFRSF5; Tumor necrosis factor receptor superfamily member 5 (TNFRSF5), also known as CD40
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28203.3 GenPept UniProtKB/Swiss-Prot:Q28203

    Gene LinkOut

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