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    FEN1 flap structure-specific endonuclease 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 616242, updated on 30-Jan-2025

    Summary

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    Official Symbol
    FEN1provided by VGNC
    Official Full Name
    flap structure-specific endonuclease 1provided by VGNC
    Primary source
    VGNC:VGNC:28947
    See related
    BGD:BT21026; EnsemblRapid:ENSBTAG00070033471
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See FEN1 in Genome Data Viewer
    Location:
    chromosome: 29
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 29 NC_037356.1 (40235336..40241632)

    Chromosome 29 - NC_037356.1Genomic Context describing neighboring genes Neighboring gene diacylglycerol lipase alpha Neighboring gene myelin regulatory factor Neighboring gene transmembrane protein 258 Neighboring gene uncharacterized LOC132344204 Neighboring gene fatty acid desaturase 1 Neighboring gene transmembrane protein 183-like Neighboring gene fatty acid desaturase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    2. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC129107

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 5'-3' exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables 5'-flap endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA-DNA hybrid ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    flap endonuclease 1
    Names
    FEN-1
    NP_001030285.1
    XP_059739017.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035113.1 → NP_001030285.1  flap endonuclease 1

      See identical proteins and their annotated locations for NP_001030285.1

      Status: PROVISIONAL

      Source sequence(s)
      BT021527
      UniProtKB/Swiss-Prot
      Q58DH8
      Related
      ENSBTAP00070046102.1, ENSBTAT00070075535.1
      Conserved Domains (3) summary
      cd09907
      Location:221 → 290
      H3TH_FEN1-Euk; H3TH domain of Flap Endonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease: Eukaryotic homologs
      cd09867
      Location:5 → 344
      PIN_FEN1; PIN domain of Flap Endonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
      PTZ00217
      Location:1 → 359
      PTZ00217; flap endonuclease-1; Provisional

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037356.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      40235336..40241632
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059883034.1 → XP_059739017.1  flap endonuclease 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3MHF6, Q58DH8, Q58DS0
      Related
      ENSBTAP00070046073.1, ENSBTAT00070075483.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q58DH8.1 GenPept UniProtKB/Swiss-Prot:Q58DH8

    Gene LinkOut

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