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    ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 508410, updated on 30-Jan-2025

    Summary

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    Official Symbol
    ARIH1provided by VGNC
    Official Full Name
    ariadne RBR E3 ubiquitin protein ligase 1provided by VGNC
    Primary source
    VGNC:VGNC:26133
    See related
    BGD:BT13948; EnsemblRapid:ENSBTAG00070025661
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ARIH1 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (19367325..19475353)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132346342 Neighboring gene uncharacterized LOC132346340 Neighboring gene transmembrane protein 202 Neighboring gene Bardet-Biedl syndrome 4 Neighboring gene microRNA mir-12031 Neighboring gene ADP dependent glucokinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC148912

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase ARIH1
    Names
    ARI-1
    Protein ariadne-1 homolog
    RING-type E3 ubiquitin transferase ARIH1
    ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1
    NP_001075183.1
    XP_005211343.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081714.2 → NP_001075183.1  E3 ubiquitin-protein ligase ARIH1

      See identical proteins and their annotated locations for NP_001075183.1

      Status: PROVISIONAL

      Source sequence(s)
      BC133645
      UniProtKB/Swiss-Prot
      A2VEA3
      UniProtKB/TrEMBL
      A0AAA9SQN4
      Related
      ENSBTAP00070034583.1, ENSBTAT00070058137.1
      Conserved Domains (3) summary
      smart00647
      Location:255 → 315
      IBR; In Between Ring fingers
      cd16626
      Location:183 → 240
      RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins
      pfam01485
      Location:337 → 377
      IBR; IBR domain, a half RING-finger domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      19367325..19475353
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005211286.4 → XP_005211343.1  E3 ubiquitin-protein ligase ARIH1 isoform X1

      UniProtKB/TrEMBL
      A0AAA9RWL4
      Conserved Domains (3) summary
      smart00647
      Location:165 → 225
      IBR; In Between Ring fingers
      cd16626
      Location:93 → 150
      RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins
      pfam01485
      Location:247 → 287
      IBR; IBR domain, a half RING-finger domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2VEA3.1 GenPept UniProtKB/Swiss-Prot:A2VEA3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.