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    ZNF573 zinc finger protein 573 [ Homo sapiens (human) ]

    Gene ID: 126231, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZNF573provided by HGNC
    Official Full Name
    zinc finger protein 573provided by HGNC
    Primary source
    HGNC:HGNC:26420
    See related
    Ensembl:ENSG00000189144 AllianceGenome:HGNC:26420
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 1.0), spleen (RPKM 0.7) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF573 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (37738302..37779586, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (40540059..40581107, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (38229203..38270226, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38186077-38186752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:38187429-38188103 Neighboring gene selenoprotein K pseudogene 1 Neighboring gene zinc finger protein 607 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10557 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10558 Neighboring gene H3K27ac hESC enhancers GRCh37_chr19:38269714-38270377 and GRCh37_chr19:38270378-38271040 Neighboring gene uncharacterized LOC105372394 Neighboring gene IST1 homolog Neighboring gene zinc finger protein 607 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A tumor-associated autoantibody panel for the detection of non-small cell lung cancer. Cai R, et al. Front Oncol, 2022. PMID 36531074, Free PMC Article
    2. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Yao Z, et al. Mol Cell, 2017 Jan 19. PMID 28065597, Free PMC Article
    3. Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism. Antoniali G, et al. Nat Commun, 2017 Oct 6. PMID 28986522, Free PMC Article
    4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Suzuki Y, et al. Genome Res, 2004 Sep. PMID 15342556, Free PMC Article
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ30921

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 573

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172689.2 → NP_001166160.1  zinc finger protein 573 isoform 2

      See identical proteins and their annotated locations for NP_001166160.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks three alternate exons, includes an additional exon, and uses an upstream start codon, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1. Both variants 2 and 5 encode the same isoform.
      Source sequence(s)
      AC016582, AK055483, AK074539, BC042170, DA778380
      UniProtKB/Swiss-Prot
      Q86YE8
      Conserved Domains (3) summary
      COG5048
      Location:156 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:496 → 516
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:172 → 197
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001172690.2 → NP_001166161.1  zinc finger protein 573 isoform 3

      See identical proteins and their annotated locations for NP_001166161.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks three alternate exons and uses an upstream start codon, compared to variant 1. The resulting isoform (3) has a longer and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK055483, BC042170, BP274132
      Consensus CDS
      CCDS59381.1
      UniProtKB/Swiss-Prot
      B7WPE1, K7EJ45, Q6P1P1, Q7Z7Q3, Q86YE8, Q8N2Q1, Q96BM3, Q96NH0
      Related
      ENSP00000440464.2, ENST00000536220.7
      Conserved Domains (5) summary
      smart00349
      Location:28 → 89
      KRAB; krueppel associated box
      COG5048
      Location:244 → 628
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:584 → 604
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:28 → 67
      KRAB; KRAB box
      pfam13465
      Location:260 → 285
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001172691.2 → NP_001166162.1  zinc finger protein 573 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks three alternate exons, uses an alternate splice site, and uses an upstream start codon, compared to variant 1. The resulting isoform (4) has a longer and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK055483, BC042170, BG572864, DA778380
      UniProtKB/Swiss-Prot
      Q86YE8
      Conserved Domains (5) summary
      smart00349
      Location:26 → 87
      KRAB; krueppel associated box
      COG5048
      Location:242 → 626
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:582 → 602
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:26 → 65
      KRAB; KRAB box
      pfam13465
      Location:258 → 283
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001172692.2 → NP_001166163.1  zinc finger protein 573 isoform 2

      See identical proteins and their annotated locations for NP_001166163.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks four alternate exons and uses an upstream start codon, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1. Both variants 2 and 5 encode the same isoform.
      Source sequence(s)
      AK055483, BC042170, DA778380, DB121870
      UniProtKB/Swiss-Prot
      Q86YE8
      Conserved Domains (3) summary
      COG5048
      Location:156 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:496 → 516
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:172 → 197
      zf-H2C2_2; Zinc-finger double domain

    5. NM_152360.4 → NP_689573.3  zinc finger protein 573 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AK055483, BC064962, DA778380
      Consensus CDS
      CCDS12508.1
      UniProtKB/Swiss-Prot
      Q86YE8
      Related
      ENSP00000340171.4, ENST00000339503.7
      Conserved Domains (4) summary
      COG5048
      Location:186 → 570
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:526 → 546
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:202 → 227
      zf-H2C2_2; Zinc-finger double domain
      pfam13900
      Location:6 → 34
      GVQW; Putative domain of unknown function

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      37738302..37779586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      40540059..40581107 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86YE8.4 GenPept UniProtKB/Swiss-Prot:Q86YE8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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