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    DPRX divergent-paired related homeobox [ Homo sapiens (human) ]

    Gene ID: 503834, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DPRXprovided by HGNC
    Official Full Name
    divergent-paired related homeoboxprovided by HGNC
    Primary source
    HGNC:HGNC:32166
    See related
    Ensembl:ENSG00000204595 MIM:611165; AllianceGenome:HGNC:32166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the DPRX homeobox gene family. Evidence of mRNA expression has not yet been found for this gene. Multiple, related processed pseudogenes have been found which are thought to reflect expression of this gene in the germ line or embryonic cells. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See DPRX in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (53601114..53637014)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (56680646..56716531)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54135253..54140268)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 813 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:54008197-54008422 Neighboring gene ribosomal protein L39 pseudogene 37 Neighboring gene vomeronasal 1 receptor 103 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54022978-54023752 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54023753-54024526 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54024527-54025300 Neighboring gene zinc finger protein 331 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54041127-54041643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15071 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:54080110-54081309 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54097943-54098874 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54098875-54099804 Neighboring gene solute carrier family 7 member 3 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54109319-54109846 Neighboring gene solute carrier family 7 member 3 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54115011-54116004 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54116005-54116999 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54117000-54117993 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54122202-54122702 Neighboring gene oligosaccharyltransferase complex subunit pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54140228-54140728 Neighboring gene RNA, 7SL, cytoplasmic 317, pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54146969-54147762 Neighboring gene uncharacterized LOC107985342 Neighboring gene nuclear RNA export factor 3 pseudogene Neighboring gene RNA, U6 small nuclear 698, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line. Booth HA, et al. Gene, 2007 Jan 31. PMID 17005330
    2. Interaction network of human early embryonic transcription factors. Gawriyski L, et al. EMBO Rep, 2024 Mar. PMID 38297188, Free PMC Article
    3. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article
    4. A census of human transcription factors: function, expression and evolution. Vaquerizas JM, et al. Nat Rev Genet, 2009 Apr. PMID 19274049
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    divergent paired-related homeobox

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012728.2 → NP_001012746.1  divergent paired-related homeobox

      See identical proteins and their annotated locations for NP_001012746.1

      Status: VALIDATED

      Source sequence(s)
      AC011487
      Consensus CDS
      CCDS33103.1
      UniProtKB/Swiss-Prot
      A6NFQ7
      Related
      ENSP00000365838.1, ENST00000376650.2
      Conserved Domains (1) summary
      pfam00046
      Location:19 → 72
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      53601114..53637014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438893.1 → XP_047294849.1  divergent paired-related homeobox isoform X1

      UniProtKB/Swiss-Prot
      A6NFQ7
      Related
      ENSP00000518423.1, ENST00000710707.1

    2. XM_011527011.4 → XP_011525313.1  divergent paired-related homeobox isoform X1

      See identical proteins and their annotated locations for XP_011525313.1

      UniProtKB/Swiss-Prot
      A6NFQ7
      Conserved Domains (1) summary
      pfam00046
      Location:19 → 72
      Homeobox; Homeobox domain

    3. XM_011527012.3 → XP_011525314.1  divergent paired-related homeobox isoform X1

      See identical proteins and their annotated locations for XP_011525314.1

      UniProtKB/Swiss-Prot
      A6NFQ7
      Conserved Domains (1) summary
      pfam00046
      Location:19 → 72
      Homeobox; Homeobox domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      56680646..56716531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321126.1 → XP_054177101.1  divergent paired-related homeobox isoform X1

      UniProtKB/Swiss-Prot
      A6NFQ7

    2. XM_054321128.1 → XP_054177103.1  divergent paired-related homeobox isoform X1

      UniProtKB/Swiss-Prot
      A6NFQ7

    3. XM_054321127.1 → XP_054177102.1  divergent paired-related homeobox isoform X1

      UniProtKB/Swiss-Prot
      A6NFQ7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NFQ7.1 GenPept UniProtKB/Swiss-Prot:A6NFQ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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