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    S100PBP S100P binding protein [ Homo sapiens (human) ]

    Gene ID: 64766, updated on 27-Nov-2024

    Summary

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    Official Symbol
    S100PBPprovided by HGNC
    Official Full Name
    S100P binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:25768
    See related
    Ensembl:ENSG00000116497 MIM:611889; AllianceGenome:HGNC:25768
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    S100PBPR
    Summary
    This gene encodes a protein that was originally identified by its interaction with S100 calcium-binding protein P. Expression of this protein has been reported to be associated with pancreatic ductal adenocarcinoma. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]
    Expression
    Broad expression in testis (RPKM 19.6), lymph node (RPKM 6.5) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See S100PBP in Genome Data Viewer
    Location:
    1p35.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (32816562..32858879)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (32673499..32718671)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (33283043..33324480)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RB binding protein 4, chromatin remodeling factor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33154443-33154943 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33160284-33161022 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33167839-33168604 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33168605-33169370 Neighboring gene syncoilin, intermediate filament protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 607 Neighboring gene Sharpr-MPRA regulatory region 2185 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33183271-33184026 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33189892-33190720 Neighboring gene Sharpr-MPRA regulatory region 8469 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33200787-33201312 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33201837-33202361 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33202362-33202885 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 608 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:33219766-33220279 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33225004-33225886 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33225887-33226770 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:33227405-33227625 Neighboring gene NHS like 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33231243-33232135 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33232136-33233029 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33235076-33235991 Neighboring gene Sharpr-MPRA regulatory region 15696 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_6796 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:33251929-33253128 Neighboring gene tyrosyl-tRNA synthetase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 697 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33269619-33270293 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33270294-33270967 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33275934-33276570 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33276571-33277206 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33282071-33282572 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33282573-33283072 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_6822 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 699 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 700 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 701 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_6850 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_6868 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33333351-33333852 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33338281-33339137 Neighboring gene uncharacterized LOC105378631 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_6918 Neighboring gene fibronectin type III domain containing 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Usefulness of S100P in diagnosis of adenocarcinoma of pancreas on fine-needle aspiration biopsy specimens. Deng H, et al. Am J Clin Pathol, 2008 Jan. PMID 18089492
    2. S100P-binding protein, S100PBP, mediates adhesion through regulation of cathepsin Z in pancreatic cancer cells. Lines KE, et al. Am J Pathol, 2012 Apr. PMID 22330678
    3. Expression of S100P and its novel binding partner S100PBPR in early pancreatic cancer. Dowen SE, et al. Am J Pathol, 2005 Jan. PMID 15632002, Free PMC Article
    4. Novel functions and targets of miR-944 in human cervical cancer cells. Xie H, et al. Int J Cancer, 2015 Mar 1. PMID 25156441, Free PMC Article
    5. S100PBP is regulated by mutated KRAS and plays a tumour suppressor role in pancreatic cancer. Srivastava K, et al. Oncogene, 2023 Nov. PMID 37794133, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. S100PBP is regulated by mutated KRAS and plays a tumour suppressor role in pancreatic cancer.
      Title: S100PBP is regulated by mutated KRAS and plays a tumour suppressor role in pancreatic cancer.
    2. Low S100PBP expression is associated with cervical cancer.
      Title: Novel functions and targets of miR-944 in human cervical cancer cells.
    3. S100P-binding protein mediates adhesion through regulation of cathepsin Z in pancreatic cancer cells.
      Title: S100P-binding protein, S100PBP, mediates adhesion through regulation of cathepsin Z in pancreatic cancer cells.
    4. S100P is a sensitive and specific marker for the detection of pancreatic ductal adenocarcinoma on FNAB specimens on cell-block and smear preparations.
      Title: Usefulness of S100P in diagnosis of adenocarcinoma of pancreas on fine-needle aspiration biopsy specimens.
    5. can be added to the genetic progression model for pancreatic ductal adenocarcinoma.
      Title: Expression of S100P and its novel binding partner S100PBPR in early pancreatic cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ12903, DKFZp313K2325

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    S100P-binding protein
    Names
    S100P binding protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031988.1 RefSeqGene

      Range
      5212..46434
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001256121.2 → NP_001243050.1  S100P-binding protein

      See identical proteins and their annotated locations for NP_001243050.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same protein.
      Source sequence(s)
      AK022965, AK090711, BX647916
      Consensus CDS
      CCDS30666.1
      UniProtKB/Swiss-Prot
      B3KR04, D3DPQ5, Q5HYH3, Q96BU1, Q9H997
      UniProtKB/TrEMBL
      A0A0S2Z5M0, A0A0S2Z5S2
      Related
      ENSP00000362575.1, ENST00000373476.5
      Conserved Domains (1) summary
      pfam15427
      Location:22 → 402
      S100PBPR; S100P-binding protein

    2. NM_022753.4 → NP_073590.2  S100P-binding protein

      See identical proteins and their annotated locations for NP_073590.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 3 both encode the same protein.
      Source sequence(s)
      AK022965, BX647916
      Consensus CDS
      CCDS30666.1
      UniProtKB/Swiss-Prot
      B3KR04, D3DPQ5, Q5HYH3, Q96BU1, Q9H997
      UniProtKB/TrEMBL
      A0A0S2Z5M0, A0A0S2Z5S2
      Related
      ENSP00000362574.5, ENST00000373475.10
      Conserved Domains (1) summary
      pfam15427
      Location:22 → 402
      S100PBPR; S100P-binding protein

    RNA

    1. NR_135106.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction and contains two alternate exons compared to variant 1. The exon combination at the 5' UTR has not been determined. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA557330, AC114493, AK090711, BX647916, KU178751

    2. NR_135107.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate exon compared to variant 1. The exon combination at the 5' UTR has not been determined. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA557330, AC114493, AK022965, AK090711, BX647916

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      32816562..32858879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541962.3 → XP_011540264.1  S100P-binding protein isoform X1

      See identical proteins and their annotated locations for XP_011540264.1

      UniProtKB/Swiss-Prot
      B3KR04, D3DPQ5, Q5HYH3, Q96BU1, Q9H997
      UniProtKB/TrEMBL
      A0A0S2Z5M0, A0A0S2Z5S2
      Conserved Domains (1) summary
      pfam15427
      Location:22 → 402
      S100PBPR; S100P-binding protein

    2. XM_047428036.1 → XP_047283992.1  S100P-binding protein isoform X2

    3. XM_047428029.1 → XP_047283985.1  S100P-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KR04, D3DPQ5, Q5HYH3, Q96BU1, Q9H997
      UniProtKB/TrEMBL
      A0A0S2Z5M0

    4. XM_011541961.3 → XP_011540263.1  S100P-binding protein isoform X1

      See identical proteins and their annotated locations for XP_011540263.1

      UniProtKB/Swiss-Prot
      B3KR04, D3DPQ5, Q5HYH3, Q96BU1, Q9H997
      UniProtKB/TrEMBL
      A0A0S2Z5M0, A0A0S2Z5S2
      Conserved Domains (1) summary
      pfam15427
      Location:22 → 402
      S100PBPR; S100P-binding protein

    5. XM_047428035.1 → XP_047283991.1  S100P-binding protein isoform X2

    6. XM_047428024.1 → XP_047283980.1  S100P-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KR04, D3DPQ5, Q5HYH3, Q96BU1, Q9H997
      UniProtKB/TrEMBL
      A0A0S2Z5M0

    7. XM_017002098.3 → XP_016857587.1  S100P-binding protein isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z5S2

    8. XM_011541963.3 → XP_011540265.1  S100P-binding protein isoform X4

      See identical proteins and their annotated locations for XP_011540265.1

      UniProtKB/TrEMBL
      A0A0S2Z5S2
      Conserved Domains (1) summary
      pfam15427
      Location:22 → 341
      S100PBPR; S100P-binding protein

    9. XM_047428038.1 → XP_047283994.1  S100P-binding protein isoform X5

    10. XM_047428037.1 → XP_047283993.1  S100P-binding protein isoform X3

    11. XM_047428039.1 → XP_047283995.1  S100P-binding protein isoform X6

    12. XM_047428023.1 → XP_047283979.1  S100P-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KR04, D3DPQ5, Q5HYH3, Q96BU1, Q9H997
      UniProtKB/TrEMBL
      A0A0S2Z5M0

    13. XM_047428040.1 → XP_047283996.1  S100P-binding protein isoform X2

    14. XM_024449177.2 → XP_024304945.1  S100P-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KR04, D3DPQ5, Q5HYH3, Q96BU1, Q9H997
      UniProtKB/TrEMBL
      A0A0S2Z5M0, A0A0S2Z5S2
      Conserved Domains (1) summary
      pfam15427
      Location:22 → 402
      S100PBPR; S100P-binding protein

    15. XM_024449176.2 → XP_024304944.1  S100P-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KR04, D3DPQ5, Q5HYH3, Q96BU1, Q9H997
      UniProtKB/TrEMBL
      A0A0S2Z5M0, A0A0S2Z5S2
      Conserved Domains (1) summary
      pfam15427
      Location:22 → 402
      S100PBPR; S100P-binding protein

    16. XM_047428041.1 → XP_047283997.1  S100P-binding protein isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      32673499..32718671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338285.1 → XP_054194260.1  S100P-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KR04, D3DPQ5, Q5HYH3, Q96BU1, Q9H997
      UniProtKB/TrEMBL
      A0A0S2Z5M0

    2. XM_054338290.1 → XP_054194265.1  S100P-binding protein isoform X2

    3. XM_054338284.1 → XP_054194259.1  S100P-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KR04, D3DPQ5, Q5HYH3, Q96BU1, Q9H997
      UniProtKB/TrEMBL
      A0A0S2Z5M0

    4. XM_054338288.1 → XP_054194263.1  S100P-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KR04, D3DPQ5, Q5HYH3, Q96BU1, Q9H997
      UniProtKB/TrEMBL
      A0A0S2Z5M0

    5. XM_054338289.1 → XP_054194264.1  S100P-binding protein isoform X2

    6. XM_054338293.1 → XP_054194268.1  S100P-binding protein isoform X4

    7. XM_054338294.1 → XP_054194269.1  S100P-binding protein isoform X5

    8. XM_054338292.1 → XP_054194267.1  S100P-binding protein isoform X3

    9. XM_054338295.1 → XP_054194270.1  S100P-binding protein isoform X6

    10. XM_054338291.1 → XP_054194266.1  S100P-binding protein isoform X2

    11. XM_054338287.1 → XP_054194262.1  S100P-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KR04, D3DPQ5, Q5HYH3, Q96BU1, Q9H997
      UniProtKB/TrEMBL
      A0A0S2Z5M0

    12. XM_054338297.1 → XP_054194272.1  S100P-binding protein isoform X2

    13. XM_054338286.1 → XP_054194261.1  S100P-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KR04, D3DPQ5, Q5HYH3, Q96BU1, Q9H997
      UniProtKB/TrEMBL
      A0A0S2Z5M0

    14. XM_054338296.1 → XP_054194271.1  S100P-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KR04, D3DPQ5, Q5HYH3, Q96BU1, Q9H997
      UniProtKB/TrEMBL
      A0A0S2Z5M0

    15. XM_054338298.1 → XP_054194273.1  S100P-binding protein isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001017406.1: Suppressed sequence

      Description
      NM_001017406.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96BU1.1 GenPept UniProtKB/Swiss-Prot:Q96BU1

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