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    TRIM34 tripartite motif containing 34 [ Homo sapiens (human) ]

    Gene ID: 53840, updated on 10-Dec-2024

    Summary

    Official Symbol
    TRIM34provided by HGNC
    Official Full Name
    tripartite motif containing 34provided by HGNC
    Primary source
    HGNC:HGNC:10063
    See related
    Ensembl:ENSG00000258659 MIM:605684; AllianceGenome:HGNC:10063
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IFP1; RNF21
    Summary
    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this gene is up-regulated by interferon. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from the upstream TRIM6 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]
    Expression
    Ubiquitous expression in spleen (RPKM 7.4), lymph node (RPKM 6.3) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TRIM34 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (5619944..5644398)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (5677835..5702296)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (5641174..5665628)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4920 Neighboring gene olfactory receptor family 52 subfamily B member 6 Neighboring gene Sharpr-MPRA regulatory region 11830 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:5617638-5618555 Neighboring gene TRIM6-TRIM34 readthrough Neighboring gene Sharpr-MPRA regulatory region 4679 Neighboring gene tripartite motif containing 5 Neighboring gene tripartite motif containing 6 Neighboring gene NANOG hESC enhancer GRCh37_chr11:5642663-5643271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4327 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4329 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4330 Neighboring gene uncharacterized LOC107984302 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:5700031-5701230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4331 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:5711125-5712324 Neighboring gene uncharacterized LOC124902620 Neighboring gene tripartite motif containing 22

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat specifically associates with TRIM34 promoter to upregulate TRIM34 expression in T cells PubMed
    capsid gag Human TRIM34 binds in vitro assembled HIV-1 CA-NC complexes PubMed
    gag The RING, B-box 2, and coiled-coil domains of TRIM34 can functionally replace the corresponding domains of rhesus monkey TRIM5alpha with respect to inhibition of HIV-1 infection through the binding of the chimeras to HIV-1 capsid complexes PubMed
    nucleocapsid gag Human TRIM34 binds in vitro assembled HIV-1 CA-NC complexes PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough TRIM6-TRIM34

    Readthrough gene: TRIM6-TRIM34, Included gene: TRIM6

    Clone Names

    • MGC176399

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM34
    Names
    interferon-responsive finger protein 1
    ring finger protein 21, interferon-responsive
    NP_001003827.1
    NP_067629.2
    NP_569074.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003827.1NP_001003827.1  E3 ubiquitin-protein ligase TRIM34 isoform 1

      See identical proteins and their annotated locations for NP_001003827.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Both variants 1 and 4 encode the same isoform (1, also known as the middle form).
      Source sequence(s)
      AB039902, AF220144, BM989990
      Consensus CDS
      CCDS31391.1
      UniProtKB/Swiss-Prot
      D3DQS7, Q9BYJ4, Q9C016, Q9HCR0, Q9HCR1, Q9HCR2
      Related
      ENSP00000422947.1, ENST00000514226.5
      Conserved Domains (3) summary
      cd00021
      Location:95132
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd15825
      Location:300485
      SPRY_PRY_TRIM34; PRY/SPRY domain in tripartite motif-containing protein 34 (TRIM34), also known as RING finger protein 21 (RNF21) or interferon-responsive finger protein (IFP1)
      cl17238
      Location:1559
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    2. NM_021616.6NP_067629.2  E3 ubiquitin-protein ligase TRIM34 isoform 1

      See identical proteins and their annotated locations for NP_067629.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as alpha) represents the longest transcript and encodes the longer isoform (1, also known as the middle form). Both variants 1 and 4 encode the same isoform.
      Source sequence(s)
      AF220143, BG682537, DB024660
      Consensus CDS
      CCDS31391.1
      UniProtKB/Swiss-Prot
      D3DQS7, Q9BYJ4, Q9C016, Q9HCR0, Q9HCR1, Q9HCR2
      Related
      ENSP00000402595.2, ENST00000429814.3
      Conserved Domains (3) summary
      cd00021
      Location:95132
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd15825
      Location:300485
      SPRY_PRY_TRIM34; PRY/SPRY domain in tripartite motif-containing protein 34 (TRIM34), also known as RING finger protein 21 (RNF21) or interferon-responsive finger protein (IFP1)
      cl17238
      Location:1559
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    3. NM_130390.2NP_569074.2  E3 ubiquitin-protein ligase TRIM34 isoform 3

      See identical proteins and their annotated locations for NP_569074.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks several 3' exons but includes a unique segment at its 3' end, compared to variant 1. The encoded isoform (3, also known as the short form) has a distinct and shorter C-terminus, compared to isoform 1. The 5' UTR is incomplete due to a lack of 5'-complete transcripts representing this variant and the presence of splicing ambiguity in the 5' region.
      Source sequence(s)
      AB039902, DA847894
      UniProtKB/Swiss-Prot
      Q9BYJ4
      Related
      ENST00000491385.1
      Conserved Domains (2) summary
      cd00021
      Location:95132
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl17238
      Location:1559
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      5619944..5644398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      5677835..5702296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_130389.3: Suppressed sequence

      Description
      NM_130389.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.