Ubxn1 UBX domain protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ubxn1provided by MGI
Official Full Name: UBX domain protein 1provided by MGI
Primary source: MGI:MGI:1289301
See related: Ensembl:ENSMUSG00000071655 AllianceGenome:MGI:1289301
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2B28; mY33K; D19Ertd721e; 4930455J02Rik
Summary: Predicted to enable several functions, including enzyme binding activity; polyubiquitin modification-dependent protein binding activity; and proteasome regulatory particle binding activity. Predicted to be involved in negative regulation of protein metabolic process. Predicted to be located in several cellular components, including dendrite; neuronal cell body; and nucleoplasm. Predicted to be part of VCP-NPL4-UFD1 AAA ATPase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in pancreas epithelium. Orthologous to human UBXN1 (UBX domain protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 89.4), CNS E11.5 (RPKM 86.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 5.88 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (8848912..8853030)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (8871548..8875666)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UBXN1 promotes liver tumorigenesis by regulating mitochondrial homeostasis.
Title: UBXN1 promotes liver tumorigenesis by regulating mitochondrial homeostasis.
Specific interaction of rat protein 2B28 with rat Homer2 may play a role in regulation of protein degradation by ubiquitin-proteasome systems and that this function may be specific to Homer2 proteins among Homer family proteins.
Title: A novel protein specifically interacting with Homer2 regulates ubiquitin-proteasome systems.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125269 (e-PCR)
- UniSTS:162091

D19Ertd721e (e-PCR), detects polymorphism
- UniSTS:167255

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	IEA Inferred from Electronic Annotation more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables K48-linked polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables K48-linked polyubiquitin modification-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables K48-linked polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables K6-linked polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables K6-linked polyubiquitin modification-dependent protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables proteasome regulatory particle binding	IEA Inferred from Electronic Annotation more info
enables proteasome regulatory particle binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of ERAD pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein K48-linked deubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein K48-linked deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein K48-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of ubiquitin-specific protease activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of VCP-NPL4-UFD1 AAA ATPase complex	IEA Inferred from Electronic Annotation more info
part_of VCP-NPL4-UFD1 AAA ATPase complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: UBX domain-containing protein 1

Names: SAPK substrate protein 1; UBA/UBX 33.3 kDa protein; protein 2B28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362044.1 → NP_001348973.1 UBX domain-containing protein 1

Status: VALIDATED

Source sequence(s)

AK150442, BY238872, BY606648, CX123666

Consensus CDS

CCDS29553.1

UniProtKB/Swiss-Prot

Q3UCP8, Q922Y1

UniProtKB/TrEMBL

A0A498WFS2

Related

ENSMUSP00000157971.2, ENSMUST00000238036.2

Conserved Domains (2) summary

cd01772
Location:210 → 293

SAKS1_UBX; SAKS1-like UBX domain

cd14302
Location:5 → 45

UBA_UBXN1; UBA domain found in UBX domain-containing protein 1 (UBXN1) and similar proteins
NM_146093.2 → NP_666205.1 UBX domain-containing protein 1

See identical proteins and their annotated locations for NP_666205.1

Status: VALIDATED

Source sequence(s)

AC129217

Consensus CDS

CCDS29553.1

UniProtKB/Swiss-Prot

Q3UCP8, Q922Y1

UniProtKB/TrEMBL

A0A498WFS2

Related

ENSMUSP00000133250.2, ENSMUST00000166407.9

Conserved Domains (2) summary

cd01772
Location:210 → 293

SAKS1_UBX; SAKS1-like UBX domain

cd14302
Location:5 → 45

UBA_UBXN1; UBA domain found in UBX domain-containing protein 1 (UBXN1) and similar proteins